ExoticRx · exoticrx.com/drugs/daptomycin
US brand names:Cubicin
Daptomycin is dosed at 5–10 mg/kg IV q24h in dogs, per Plumb's Veterinary Drug Handbook, 9th Ed. Verify against current literature before clinical use.
Binds to bacterial cell membranes causing rapid depolarization, loss of membrane potential, and cell death.
Monitor CPK levels for myopathy. Not effective for pneumonia (inactivated by surfactant). Renal dose adjustment needed.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.