ExoticRx · exoticrx.com/drugs/diethylcarbamazine
US brand names:Filaribits, DEC
Diethylcarbamazine is dosed at 6.6 mg/kg PO q24h in dogs, per Verified against Papich/Saunders Handbook of Veterinary Drugs, 4th Ed, p.264 (2026-08-01).. Verify against current literature before clinical use.
Sensitizes microfilariae to host immune attack. Exact mechanism unclear; may involve inhibition of arachidonic acid metabolism in parasites.
CONTRAINDICATED in heartworm-positive dogs (anaphylaxis from microfilaria die-off). Must test negative before starting. Daily dosing required. Largely replaced by monthly preventatives.
Species references:All Dog (Domestic) drugs
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| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 6.6 mg/kg | q24h | Strong | Verified against Papich/Saunders Handbook of Veterinary Drugs, 4th Ed, p.264 (2026-08-01). |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.