Equine · Equus caballus · typical adult weight 350.00–700.00 kg
Dinoprost Tromethamine (Livestock) is dosed at 5–10 mg total dose IM Once in horses, per LUTALYSE Injection (dinoprost tromethamine 5 mg/mL), Zoetis - DailyMed setid 6d462721-ece7-4fef-aef1-e5bb95dd0243, Mares section. [CORRECTED - the previously cited setid 38c5cefd-b3d2-41d4-a2fb-0d6c45d02529 is LUTALYSE HighCon 12.5 mg/mL, whose label reads "For use in cattle only. Not for use in horses and swine."] Plus Plumb's 10th ed printed p.407 HORSES.. Dinoprost Tromethamine (Livestock) is used in horses for Estrus synchronization, Luteolysis, endometritis treatment. Routes documented in horses: IM. A typical adult horse weighs 350.00–700.00 kg. ExoticRx lists 2 cited dose rules for Dinoprost Tromethamine (Livestock) in horses, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Lutalyse, ProstaMate
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IM | 5–10 mg total dosemax 10 mg total | Once | Single injection | Estrus synchronization | Strong | LUTALYSE Injection (dinoprost tromethamine 5 mg/mL), Zoetis - DailyMed setid 6d462721-ece7-4fef-aef1-e5bb95dd0243, Mares section. [CORRECTED - the previously cited setid 38c5cefd-b3d2-41d4-a2fb-0d6c45d02529 is LUTALYSE HighCon 12.5 mg/mL, whose label reads "For use in cattle only. Not for use in horses and swine."] Plus Plumb's 10th ed printed p.407 HORSES. |
| IM | 5–10 mg total | single dose | — | Luteolysis, endometritis treatment | Strong | Lutalyse sterile - dinoprost trimethamine injection, solution [US product label]. Kalamazoo, MI: Zoetis; 2016. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=38c5cefd-b3d2-41d4-a2fb-0d6c45d02529 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.434 (2026-08-01). — Plumb's 10th ed (held) printed p.405, Dinoprost monograph spanning p.405-408; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
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Natural prostaglandin F2-alpha that causes luteolysis (regression of the corpus luteum), resulting in a decline in progesterone and return to estrus. Also causes uterine contraction and cervical relaxation.
Do not handle if pregnant or have asthma — absorbed through skin and may cause bronchospasm or abortion. Wear protective gloves. Transient side effects include sweating, increased respiration, and mild colic in mares.
Species-specific contraindications and adverse-reaction reports for horses may differ from canine / feline reference data — consult the primary citations listed with each rule.
Dinoprost Tromethamine (Livestock) dose ranges in horses, with cited source references: IM 5–10 mg total dose Once; IM 5–10 mg total single dose. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Dinoprost Tromethamine (Livestock) in horses: IM.
Cited course lengths for Dinoprost Tromethamine (Livestock) in horses include: Single injection. Duration depends on the indication — match it to the specific dose rule in the table above.
Dinoprost Tromethamine (Livestock) is indicated in horses for: Estrus synchronization, Luteolysis, endometritis treatment.
These are general warnings for Dinoprost Tromethamine (Livestock) across species; consult the horse dosing table above for species-specific guidance. Do not handle if pregnant or have asthma — absorbed through skin and may cause bronchospasm or abortion. Wear protective gloves. Transient side effects include sweating, increased respiration, and mild colic in mares.
Why a species-specific page? Dinoprost Tromethamine (Livestock) pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in horses — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.