What is Emodepside-Praziquantel Topical used for?

Emodepside-Praziquantel Topical is indicated for: hookworms, Nematodes (incl. oxyurids), Nematodes (oxyurids), Roundworms, tapeworms, Trichostrongylus colubriformis.

Which species have cited Emodepside-Praziquantel Topical dosing data?

Emodepside-Praziquantel Topical dosing in the ExoticRx formulary covers 5 species: Cat (Domestic), Rabbit (Domestic), Red-eared Slider, Russian Tortoise, Sulcata Tortoise.

Is Emodepside-Praziquantel Topical a controlled substance?

Emodepside-Praziquantel Topical is not federally scheduled in the US. Controlled-drug status differs by country — verify your local rules.

What are the warnings or contraindications for Emodepside-Praziquantel Topical?

Cats only (FDA-approved). Topical application avoids pilling difficulty. Do not apply to broken skin. Oral ingestion during grooming may cause hypersalivation.

What are the side effects of Emodepside-Praziquantel Topical?

Reported side effects, adverse reactions, and contraindications for Emodepside-Praziquantel Topical: Cats only (FDA-approved). Topical application avoids pilling difficulty. Do not apply to broken skin. Oral ingestion during grooming may cause hypersalivation.

How does Emodepside-Praziquantel Topical work?

Emodepside acts on latrophilin receptors causing nematode paralysis; praziquantel disrupts cestode tegument. Combination covers roundworms, hookworms, and tapeworms.

Emodepside-Praziquantel Topical

US brand names:Profender

Calculate dosage

Sourced from published veterinary references. Awaiting credentialed clinical reviewer — our editorial process.

Emodepside-Praziquantel Topical is dosed at 0.14 ml/kg Topical (spot-on) once in rabbits, per Carpenter's Exotic Animal Formulary 6th ed, Table 10.3 (Antiparasitic Agents Used in Rabbits): 'Emodepside 2.1 percent/praziquantel 8.6 percent (Profender, Bayer) | 0.14 mL/kg topically once194 | Trichostrongylus colubriformis, studies performed in laboratory animals (e.g., rats, rabbits) suggest that emodepside may interfere with fetal development in those species'. Carpenter ref 194 = Plumb DC, Plumb's Veterinary Drug Handbook, 9th ed., 2018. THE 10th EDITION DOES NOT PRINT A RABBIT DOSAGE FOR THIS DRUG and must not be cited as the source of the figure. Verify against current literature before clinical use.

Drug Class

Antiparasitic

Routes

TOPICAL

Indications

hookwormsNematodes (incl. oxyurids)

Sample dosing (1 of 5 cited rules)

A dog/cat sample is shown here. Cited dosing for all 5 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.

Species	Route	Dose	Frequency	Evidence	Source
Cat (Domestic)	TOPICAL	Do not apply to broken skin	Single application; repeat in 30 days if needed	Strong	Profender - 2-(cyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-4h-pyrazino(2,1-a)isoquinolin-4-one, emodepside solution for cats [US product label]. In: Elanco; 2021. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=31f0a4ec-2a29-4de5-971b-633e109b276d — Plumb's 10th ed printed p.442, Emodepside/Praziquantel monograph spanning p.442-444.

Backed by 5 published sourcesShow

· 462. Tang PK, Blake D, Hedley J, et al. Efficacy of a topical formulation containing emodepside and praziquantel (Profender®, Bayer) against nematodes in captive tortoises. J Herp Med Surg. 2017;27:116-122. — Source: Carpenter's Exotic Animal Formulary, 6th Ed, p.225 doi:10.5818/17-04-107.1 — Carpenter's Exotic Animal Formulary 6th ed, Table 4.4 (Antiparasitic Agents Used in Reptiles).
· Carpenter's Exotic Animal Formulary 6th ed, Table 10.3 (Antiparasitic Agents Used in Rabbits): 'Emodepside 2.1 percent/praziquantel 8.6 percent (Profender, Bayer) | 0.14 mL/kg topically once194 | Trichostrongylus colubriformis, studies performed in laboratory animals (e.g., rats, rabbits) suggest that emodepside may interfere with fetal development in those species'. Carpenter ref 194 = Plumb DC, Plumb's Veterinary Drug Handbook, 9th ed., 2018. THE 10th EDITION DOES NOT PRINT A RABBIT DOSAGE FOR THIS DRUG and must not be cited as the source of the figure.
·

Profender - 2-(cyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-4h-pyrazino(2,1-a)isoquinolin-4-one, emodepside solution for cats [US product label]. In: Elanco; 2021. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=31f0a4ec-2a29-4de5-971b-633e109b276d — Plumb's 10th ed printed p.442, Emodepside/Praziquantel monograph spanning p.442-444.

· Tang PK, Blake D, Hedley J, et al. Efficacy of a topical formulation containing emodepside and praziquantel (Profender, Bayer) against nematodes in captive tortoises. J Herp Med Surg. 2017;27:116-122. — Source: Carpenter's Exotic Animal Formulary, 6th Ed, p.225 — Carpenter's Exotic Animal Formulary 6th ed, Table 4.4 (Antiparasitic Agents Used in Reptiles).

· Tang PK, Blake D, Hedley J, et al. Efficacy of a topical formulation containing emodepside and praziquantel (Profender®, Bayer) against nematodes in captive tortoises. J Herp Med Surg. 2017;27:116-122. — Source: Carpenter's Exotic Animal Formulary, 6th Ed, p.225 doi:10.5818/17-04-107.1 — Carpenter's Exotic Animal Formulary 6th ed, Table 4.4 (Antiparasitic Agents Used in Reptiles).

Emodepside-Praziquantel Topical

Drug Class

Routes

Indications

Mechanism of Action

Side effects & warnings

Species with Emodepside-Praziquantel Topical dosing data (5 dose rules)

Evidence levels across 5 dose rules

Sample dosing (1 of 5 cited rules)

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Emodepside-Praziquantel Topical

Drug Class

Routes

Indications

Mechanism of Action

Side effects & warnings

Species with Emodepside-Praziquantel Topical dosing data (5 dose rules)

Evidence levels across 5 dose rules

Sample dosing (1 of 5 cited rules)

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