ExoticRx · exoticrx.com/drugs/emodepside-praziquantel-topical
US brand names:Profender
Emodepside acts on latrophilin receptors causing nematode paralysis; praziquantel disrupts cestode tegument. Combination covers roundworms, hookworms, and tapeworms.
Cats only (FDA-approved). Topical application avoids pilling difficulty. Do not apply to broken skin. Oral ingestion during grooming may cause hypersalivation.
Species references:All Cat (Domestic) drugs
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| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Cat (Domestic) | TOPICAL | FDA-approved for cats | Single application; repeat in 30 days if needed | Strong | Profender - 2-(cyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-4h-pyrazino(2,1-a)isoquinolin-4-one, emodepside solution for cats [US product label]. In: Elanco; 2021. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=31f0a4ec-2a29-4de5-971b-633e109b276d — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.471 (2026-08-01). |
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