Which species have cited Emodepside-Praziquantel Topical dosing data?

Emodepside-Praziquantel Topical dosing in the ExoticRx formulary covers 5 species: Cat (Domestic), Rabbit (Domestic), Red-eared Slider, Russian Tortoise, Sulcata Tortoise.

Is Emodepside-Praziquantel Topical a controlled substance?

Emodepside-Praziquantel Topical is not federally scheduled in the US. Controlled-drug status differs by country — verify your local rules.

Emodepside-Praziquantel Topical

US brand names:Profender

Calculate dosage

Sourced from published veterinary references. Awaiting credentialed clinical reviewer — our editorial process.

Emodepside-Praziquantel Topical is dosed at 1 ml/kg Topical (spot-on) once in red-eared sliders, per Tang PK, Blake D, Hedley J, et al. Efficacy of a topical formulation containing emodepside and praziquantel (Profender, Bayer) against nematodes in captive tortoises. J Herp Med Surg. 2017;27:116-122. — Source: Carpenter's Exotic Animal Formulary, 6th Ed, p.225 — Carpenter's Exotic Animal Formulary 6th ed, Table 4.4 (Antiparasitic Agents Used in Reptiles). The copy held is an ebook conversion with no printed page numbers, so the table — not the page — is the citable location. — SOURCE EDITION: Carpenter's Exotic Animal Formulary — ISBN 9780323833929, https://openlibrary.org/isbn/9780323833929. Verify against current literature before clinical use.

Drug Class

Antiparasitic

Routes

TOPICAL

Indications

hookwormsNematodes (incl. oxyurids)Nematodes (oxyurids)RoundwormstapewormsTrichostrongylus colubriformis

Mechanism of Action

Emodepside acts on latrophilin receptors causing nematode paralysis; praziquantel disrupts cestode tegument. Combination covers roundworms, hookworms, and tapeworms.

Side effects & warnings

Cats only (FDA-approved). Topical application avoids pilling difficulty. Do not apply to broken skin. Oral ingestion during grooming may cause hypersalivation.

Species with Emodepside-Praziquantel Topical dosing data (5 dose rules)

Cat (Domestic)Rabbit (Domestic)Red-eared Slider Russian Tortoise Sulcata Tortoise

Species references:All Cat (Domestic) drugs All Rabbit (Domestic) drugs All Red-eared Slider drugs All Russian Tortoise drugs All Sulcata Tortoise drugs

Evidence levels across 5 dose rules

Strong×1Weak×2Moderate×2

Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.

Backed by 5 published sources

· 462. Tang PK, Blake D, Hedley J, et al. Efficacy of a topical formulation containing emodepside and praziquantel (Profender®, Bayer) against nematodes in captive tortoises. J Herp Med Surg. 2017;27:116-122. — Source: Carpenter's Exotic Animal Formulary, 6th Ed, p.225 doi:10.5818/17-04-107.1 — Carpenter's Exotic Animal Formulary 6th ed, Table 4.4 (Antiparasitic Agents Used in Reptiles). The copy held is an ebook conversion with no printed page numbers, so the table — not the page — is the citable location. — SOURCE EDITION: Carpenter's Exotic Animal Formulary — ISBN 9780323833929, https://openlibrary.org/isbn/9780323833929
· Carpenter's Exotic Animal Formulary 6th ed, Table 10.3 (Antiparasitic Agents Used in Rabbits): 'Emodepside 2.1 percent/praziquantel 8.6 percent (Profender, Bayer) | 0.14 mL/kg topically once194 | Trichostrongylus colubriformis, studies performed in laboratory animals (e.g., rats, rabbits) suggest that emodepside may interfere with fetal development in those species'. Carpenter ref 194 = Plumb DC, Plumb's Veterinary Drug Handbook, 9th ed., 2018. THE HELD 10th EDITION DOES NOT PRINT A RABBIT DOSAGE FOR THIS DRUG and must not be cited as the source of the figure.

Sample dosing (1 of 5 cited rules)

A dog/cat sample is shown here. Cited dosing for all 5 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.

Species	Route	Dose	Frequency	Evidence	Source
Cat (Domestic)	TOPICAL	Do not apply to broken skin	Single application; repeat in 30 days if needed	Strong	Profender - 2-(cyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-4h-pyrazino(2,1-a)isoquinolin-4-one, emodepside solution for cats [US product label]. In: Elanco; 2021. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=31f0a4ec-2a29-4de5-971b-633e109b276d — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.471 (2026-08-01). — Plumb's 10th ed (held) printed p.442, Emodepside/Praziquantel monograph spanning p.442-444; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207

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