Equine · Equus caballus · typical adult weight 350.00–700.00 kg
Enrofloxacin is dosed at 5–7.5 mg/kg IV q24h in horses, per Haggett EF, Wilson WD. Overview of the use of antimicrobials for the treatment of bacterial infections in horses. Equine Vet Educ. 2008;20(8):433-448. doi:10.2746/095777308x338893 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.480 (2026-08-01). — Plumb's 10th ed (held) printed p.453, Enrofloxacin monograph spanning p.450-454; page located 2026-08-05 from the book's own running heads, and carries this exact dose under the matching species heading. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Enrofloxacin is used in horses for Bacterial infection, Susceptible bacterial infections. Routes documented in horses: IV. A typical adult horse weighs 350.00–700.00 kg. ExoticRx lists 2 cited dose rules for Enrofloxacin in horses, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Baytril
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 5–7.5 mg/kg | q24h | 5-10 days | Bacterial infection |
| Moderate |
| Haggett EF, Wilson WD. Overview of the use of antimicrobials for the treatment of bacterial infections in horses. Equine Vet Educ. 2008;20(8):433-448. doi:10.2746/095777308x338893 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.480 (2026-08-01). — Plumb's 10th ed (held) printed p.453, Enrofloxacin monograph spanning p.450-454; page located 2026-08-05 from the book's own running heads, and carries this exact dose under the matching species heading. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
| IV | 5–7.5 mg/kg | q24h | 5-10 days | Susceptible bacterial infections | Moderate | Haggett EF, Wilson WD. Overview of the use of antimicrobials for the treatment of bacterial infections in horses. Equine Vet Educ. 2008;20(8):433-448. doi:10.2746/095777308x338893 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.480 (2026-08-01). — Plumb's 10th ed (held) printed p.453, Enrofloxacin monograph spanning p.450-454; page located 2026-08-05 from the book's own running heads, and carries this exact dose under the matching species heading. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 5 | IV | Papich Saunders Handbook of Veterinary Drugs, 4th edp.317 | • 5 mg/kg q24h IV. |
| 7.5–10 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.317 | • 7.5-10 mg/kg q24h PO. |
| 5 | IM | Papich Saunders Handbook of Veterinary Drugs, 4th edp.317 | • 5 mg/kg of 100 mg/mL solution (Baytril-100) IM, once per day (rotate injection |
| 7.5–12.5 | SC | Papich Saunders Handbook of Veterinary Drugs, 4th edp.317 | • Single dose: 7.5-12.5 mg/kg once SQ (3.4-5.7 mL per 100 pounds). |
| 2.5–5 |
Need the exact dose for your patient?
These ranges are per kg. Enter your horse's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Inhibits bacterial DNA gyrase and topoisomerase IV, preventing DNA replication and transcription.
Avoid in growing animals (cartilage damage). Do NOT use in cats at doses >5mg/kg (retinal toxicity). Avoid concurrent use with theophylline.
Species-specific contraindications and adverse-reaction reports for horses may differ from canine / feline reference data — consult the primary citations listed with each rule.
Enrofloxacin dose ranges in horses, with cited source references: IV 5–7.5 mg/kg q24h; IV 5–7.5 mg/kg q24h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Enrofloxacin in horses: IV.
Cited course lengths for Enrofloxacin in horses include: 5-10 days. Duration depends on the indication — match it to the specific dose rule in the table above.
Enrofloxacin is indicated in horses for: Bacterial infection, Susceptible bacterial infections.
These are general warnings for Enrofloxacin across species; consult the horse dosing table above for species-specific guidance. Avoid in growing animals (cartilage damage). Do NOT use in cats at doses >5mg/kg (retinal toxicity). Avoid concurrent use with theophylline.
Why a species-specific page? Enrofloxacin pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in horses — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.
| SC |
| Papich Saunders Handbook of Veterinary Drugs, 4th edp.317 |
| • Multiple-dose: 2.5-5 mg/kg SQ (1.1-2.3 mL per 100 pounds) once daily for 3-5 days. |
| 7.5 | SC | Papich Saunders Handbook of Veterinary Drugs, 4th edp.317 | • 7.5 mg/kg SQ, behind the ear, once. |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.