Equine · Equus caballus · typical adult weight 350.00–700.00 kg
Amikacin is dosed at 250–500 mg per joint INTRA-ARTICULAR q24-48h in horses, per Plumb's Veterinary Drug Handbook, 9th Ed. Amikacin is used in horses for Septic arthritis (local), Gram-negative sepsis. Routes documented in horses: INTRA-ARTICULAR, IV. A typical adult horse weighs 350.00–700.00 kg. ExoticRx lists 2 cited dose rules for Amikacin in horses, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Amiglyde-V, Amikin
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| INTRA-ARTICULAR | 250–500 mg per joint | q24-48h | — | Septic arthritis (local) | Moderate | Plumb's Veterinary Drug Handbook, 9th Ed |
| IV | 10 mg/kg | q24h (once daily) | 5-7 days | Gram-negative sepsis | Strong | Plumb's Veterinary Drug Handbook, 9th Ed, p.76-77 — Amikacin, Systemic, Dosages, HORSES (adults) |
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Irreversibly binds 30S ribosomal subunit, inhibiting bacterial protein synthesis. Concentration-dependent bactericidal activity.
Nephrotoxic and ototoxic. Monitor renal function (BUN, creatinine). Ensure adequate hydration. Avoid concurrent use with other nephrotoxic drugs. Neuromuscular blockade risk.
Species-specific contraindications and adverse-reaction reports for horses may differ from canine / feline reference data — consult the primary citations listed with each rule.
Amikacin dose ranges in horses, with cited source references: INTRA-ARTICULAR 250–500 mg per joint q24-48h; IV 10 mg/kg q24h (once daily). Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Amikacin in horses: INTRA-ARTICULAR, IV.
Cited course lengths for Amikacin in horses include: 5-7 days. Duration depends on the indication — match it to the specific dose rule in the table above.
Amikacin is indicated in horses for: Septic arthritis (local), Gram-negative sepsis.
These are general warnings for Amikacin across species; consult the horse dosing table above for species-specific guidance. Nephrotoxic and ototoxic. Monitor renal function (BUN, creatinine). Ensure adequate hydration. Avoid concurrent use with other nephrotoxic drugs. Neuromuscular blockade risk.
Why a species-specific page? Amikacin pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in horses — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.