ExoticRx · exoticrx.com/drugs/eplerenone
US brand names:Inspra
Eplerenone is dosed at 0.5–2 mg/kg PO q12-24h in dogs, per Source not established. The citation previously shown here named no retrievable document; a literature search on 2026-07-31 found no source that states this dose for this species and route. Treat as unverified and confirm against a primary reference before clinical use.. Verify against current literature before clinical use.
Selective mineralocorticoid receptor antagonist that blocks aldosterone at the receptor level, reducing sodium reabsorption and potassium excretion without anti-androgenic effects.
Monitor potassium — hyperkalemia risk. Avoid with potassium-sparing diuretics. Less gynecomastia than spironolactone.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 0.5–2 mg/kg | q12-24h | Weak | Source not established. The citation previously shown here named no retrievable document; a literature search on 2026-07-31 found no source that states this dose for this species and route. Treat as unverified and confirm against a primary reference before clinical use. |
| Cat (Domestic) | PO | 0.5–1.5 mg/kg | q12-24h | Extrapolated | Source not established. The citation previously shown here named no retrievable document; a literature search on 2026-07-31 found no source that states this dose for this species and route. Treat as unverified and confirm against a primary reference before clinical use. |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.