ExoticRx · exoticrx.com/drugs/fipronil
US brand names:Frontline
Contraindicated in Rabbit
Fipronil is dosed at 6.7 mg/kg TOPICAL q30d in dogs, per Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1480 (2026-08-01).. Verify against current literature before clinical use.
Blocks GABA-gated chloride channels in invertebrate nervous system, causing hyperexcitation and death of fleas and ticks.
TOXIC to rabbits. External use only. May cause transient skin irritation. Seizures reported in rabbits — do NOT use in rabbits. Safe in dogs and cats.
Species references:All Dog (Domestic) drugs
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A dog/cat sample is shown here. Cited dosing for all 1 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | TOPICAL | 6.7 mg/kg | q30d | Strong | Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1480 (2026-08-01). |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.