ExoticRx · exoticrx.com/drugs/fipronil
US brand names:Frontline
Contraindicated in Rabbit
Fipronil is dosed at 7.5 mg/kg topical q30-60d in mice, per 122. Meredith A. BSAVA Small Animal Formulary: Part B: Exotic Pets, British Small Animal Veterinary Association, Quedgeley, Gloucester, UK; 2015. — Source: Carpenter's Exotic Animal Formulary, 6th Ed, p.777 — Carpenter's Exotic Animal Formulary 6th ed, Table 9.2 (Antiparasitic Agents Used in Rodents). The copy held is an ebook conversion with no printed page numbers, so the table — not the page — is the citable location. — SOURCE EDITION: BSAVA Small Animal Formulary, Part B — Exotic Pets — ISBN 9781910443712, ; Carpenter's Exotic Animal Formulary — ISBN 9780323833929, . Verify against current literature before clinical use.
Blocks GABA-gated chloride channels in invertebrate nervous system, causing hyperexcitation and death of fleas and ticks.
TOXIC to rabbits. External use only. May cause transient skin irritation. Seizures reported in rabbits — do NOT use in rabbits. Safe in dogs and cats.
Species references:All Dog (Domestic) drugsAll Mouse drugsAll Pet Rat drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 3 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | TOPICAL | 6.7 applicator per weight band (NOT mg/kg) | q30d | Strong | Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1480 (2026-08-01). — Plumb's 10th ed (held) printed p.1453, Fipronil/Fipronil Combinations, Topical monograph spanning p.1453-1455; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 BASIS CORRECTED 2026-08-13: served as exact mg/kg, which the calculator multiplies by body weight to produce a milligram figure for a product that is a fixed-volume topical pipette. Plumb's 10th ed, Fipronil Topical monograph, corpus p.1481, Dosage Forms: "Fipronil 9.7% (spot-on solution) ... single-dose applicators 0.5 mL in packages of 3 and 6", labelled "for use on cats and kittens 8 weeks of age or older and over 0.7 kg" - i.e. selected by WEIGHT BAND, not calculated per kilogram. The served 6.7 mg/kg is a derived figure, not a printed dose. Read from the page 2026-08-13. |
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