What is Fluticasone-Salmeterol used for?

Fluticasone-Salmeterol is indicated for: bronchospasm, Chronic bronchitis, Moderate-severe feline asthma.

Which species have cited Fluticasone-Salmeterol dosing data?

Fluticasone-Salmeterol dosing in the ExoticRx formulary covers 2 species: Cat (Domestic), Dog (Domestic).

Is Fluticasone-Salmeterol a controlled substance?

Fluticasone-Salmeterol is not federally scheduled in the US. Controlled-drug status differs by country — verify your local rules.

What are the side effects of Fluticasone-Salmeterol?

Reported side effects, adverse reactions, and contraindications for Fluticasone-Salmeterol: Requires spacer/mask for veterinary use. Used for moderate-severe feline asthma. Step-down to ICS alone when controlled.

Fluticasone-Salmeterol

US brand names:Advair, AirDuo

Calculate dosage

Sourced from published veterinary references. Awaiting credentialed clinical reviewer — our editorial process.

Fluticasone-Salmeterol is dosed at 44–220 mcg fluticasone/tx Inhaled q12h in cats, per Cohn LA, DeClue AE, Cohen RL, Reinero CR. Effects of fluticasone propionate dosage in an experimental model of feline asthma. J Feline Med Surg. 2010;12(2):91-96. doi:10.1016/j.jfms.2009.05.024; Padrid P. Diagnosis and therapy of feline asthma. Paper presented at: ACVIM; 2006. PMID: 42320919; Padrid P. Inhaled steroids to treat feline lower airway disease: 300 cases 1995-2007. Paper presented at: ACVIM; 2008. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.580 (2026-08-01).. Verify against current literature before clinical use.

Drug Class

Respiratory

Routes

Inhaled

Indications

bronchospasmChronic bronchitisModerate-severe feline asthma

Mechanism of Action

Combination of inhaled corticosteroid (fluticasone) for anti-inflammatory effect with long-acting beta-2 agonist (salmeterol) for sustained bronchodilation.

Side effects & warnings

Requires spacer/mask for veterinary use. Used for moderate-severe feline asthma. Step-down to ICS alone when controlled.

Species with Fluticasone-Salmeterol dosing data (2 dose rules)

Cat (Domestic)Dog (Domestic)

Species references:All Cat (Domestic) drugs All Dog (Domestic) drugs

Evidence levels across 2 dose rules

Weak×1Moderate×1

Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.

Backed by 2 published sources

· Cohn LA, DeClue AE, Cohen RL, Reinero CR. Effects of fluticasone propionate dosage in an experimental model of feline asthma. J Feline Med Surg. 2010;12(2):91-96. doi:10.1016/j.jfms.2009.05.024; Padrid P. Diagnosis and therapy of feline asthma. Paper presented at: ACVIM; 2006. PMID: 42320919; Padrid P. Inhaled steroids to treat feline lower airway disease: 300 cases 1995-2007. Paper presented at: ACVIM; 2008. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.580 (2026-08-01).
· Source not established. The citation previously shown here named no retrievable document; a literature search on 2026-07-31 found no source that states this dose for this species and route. Treat as unverified and confirm against a primary reference before clinical use.

Sample dosing (2 of 2 cited rules)

A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.

Species	Route	Dose	Frequency	Evidence	Source
Cat (Domestic)	Inhaled	44–220 mcg fluticasone/tx	q12h	Moderate	Cohn LA, DeClue AE, Cohen RL, Reinero CR. Effects of fluticasone propionate dosage in an experimental model of feline asthma. J Feline Med Surg. 2010;12(2):91-96. doi:10.1016/j.jfms.2009.05.024; Padrid P. Diagnosis and therapy of feline asthma. Paper presented at: ACVIM; 2006. PMID: 42320919; Padrid P. Inhaled steroids to treat feline lower airway disease: 300 cases 1995-2007. Paper presented at: ACVIM; 2008. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.580 (2026-08-01).
Dog (Domestic)	Inhaled	44–220 mcg fluticasone/tx	q12h	Weak

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