Cat · Felis catus · typical adult weight 2.50–7.00 kg
Glipizide is dosed at 2.5–5 mg per cat PO q12h in cats, per Reusch CE. Chapter 7: Feline Diabetes Mellitus. In: Feldman EC, Nelson RW, Reusch CE, Scott-Moncrieff JCR, eds. Canine and Feline Endocrinology. 4th ed. Elsevier Saunders; 2015:258-314. doi:10.1016/b978-1-4557-4456-5.00007-9; Behrend E, Holford A, Lathan P, Rucinsky R, Schulman R. 2018 AAHA Diabetes Management Guidelines for Dogs and Cats. J Am Anim Hosp Assoc. 2018;54(1):1-21. doi:10.5326/jaaha-ms-6822 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.608 (2026-08-01). — Plumb's 10th ed (held) printed p.580, Glipizide monograph spanning p.580-581; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Glipizide is used in cats for Diabetes mellitus (if insulin refused). Routes documented in cats: PO. A typical adult cat weighs 2.50–7.00 kg. ExoticRx lists 1 cited dose rule for Glipizide in cats, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Glucotrol
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 2.5–5 mg per catmax 5 mg total | q12h | Long-term; reassess every 2-4 weeks | Diabetes mellitus (if insulin refused) | Moderate | Reusch CE. Chapter 7: Feline Diabetes Mellitus. In: Feldman EC, Nelson RW, Reusch CE, Scott-Moncrieff JCR, eds. Canine and Feline Endocrinology. 4th ed. Elsevier Saunders; 2015:258-314. doi:10.1016/b978-1-4557-4456-5.00007-9; Behrend E, Holford A, Lathan P, Rucinsky R, Schulman R. 2018 AAHA Diabetes Management Guidelines for Dogs and Cats. J Am Anim Hosp Assoc. 2018;54(1):1-21. doi:10.5326/jaaha-ms-6822 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.608 (2026-08-01). — Plumb's 10th ed (held) printed p.580, Glipizide monograph spanning p.580-581; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mg/animal) | Route | Source | As printed |
|---|---|---|---|
| 2.5–7.5 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.384 | • 2.5-7.5 mg/cat q12h PO. Usual dose is 2.5 mg/cat initially, then increase to |
| 2.5 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.384 | • 2.5-7.5 mg/cat q12h PO. Usual dose is 2.5 mg/cat initially, then increase to |
| 5 | — | Papich Saunders Handbook of Veterinary Drugs, 4th edp.384 | 5 mg/cat q12h. |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.
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Stimulates insulin secretion from functioning pancreatic beta cells by blocking ATP-sensitive potassium channels.
Cats only (dogs are primarily Type 1 DM). Requires functional beta cells. Hypoglycemia risk. Hepatotoxicity reported in cats. Not first-line (insulin preferred). May cause vomiting and hepatic lipidosis.
Species-specific contraindications and adverse-reaction reports for cats may differ from canine / feline reference data — consult the primary citations listed with each rule.
Glipizide dose range in cats, with cited source references: PO 2.5–5 mg per cat q12h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Glipizide in cats: PO.
Cited course lengths for Glipizide in cats include: Long-term; reassess every 2-4 weeks. Duration depends on the indication — match it to the specific dose rule in the table above.
Glipizide is indicated in cats for: Diabetes mellitus (if insulin refused).
These are general warnings for Glipizide across species; consult the cat dosing table above for species-specific guidance. Cats only (dogs are primarily Type 1 DM). Requires functional beta cells. Hypoglycemia risk. Hepatotoxicity reported in cats. Not first-line (insulin preferred). May cause vomiting and hepatic lipidosis.
Why a species-specific page? Glipizide pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in cats — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.