ExoticRx · exoticrx.com/drugs/glipizide
US brand names:Glucotrol
Glipizide is dosed at 2.5–5 mg per cat PO q12h in cats, per Reusch CE. Chapter 7: Feline Diabetes Mellitus. In: Feldman EC, Nelson RW, Reusch CE, Scott-Moncrieff JCR, eds. Canine and Feline Endocrinology. 4th ed. Elsevier Saunders; 2015:258-314. doi:10.1016/b978-1-4557-4456-5.00007-9; Behrend E, Holford A, Lathan P, Rucinsky R, Schulman R. 2018 AAHA Diabetes Management Guidelines for Dogs and Cats. J Am Anim Hosp Assoc. 2018;54(1):1-21. doi:10.5326/jaaha-ms-6822 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.608 (2026-08-01).. Verify against current literature before clinical use.
Stimulates insulin secretion from functioning pancreatic beta cells by blocking ATP-sensitive potassium channels.
Cats only (dogs are primarily Type 1 DM). Requires functional beta cells. Hypoglycemia risk. Hepatotoxicity reported in cats. Not first-line (insulin preferred). May cause vomiting and hepatic lipidosis.
Species references:All Cat (Domestic) drugs
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A dog/cat sample is shown here. Cited dosing for all 1 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Cat (Domestic) | PO | 2.5–5 mg per cat | q12h | Moderate | Reusch CE. Chapter 7: Feline Diabetes Mellitus. In: Feldman EC, Nelson RW, Reusch CE, Scott-Moncrieff JCR, eds. Canine and Feline Endocrinology. 4th ed. Elsevier Saunders; 2015:258-314. doi:10.1016/b978-1-4557-4456-5.00007-9; Behrend E, Holford A, Lathan P, Rucinsky R, Schulman R. 2018 AAHA Diabetes Management Guidelines for Dogs and Cats. J Am Anim Hosp Assoc. 2018;54(1):1-21. doi:10.5326/jaaha-ms-6822 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.608 (2026-08-01). |
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