ExoticRx · exoticrx.com/drugs/hydroxocobalamin
US brand names:Cyanokit
Hydroxocobalamin is dosed at 70 mg/kg IV Single IV infusion over 15 minutes in dogs, per Plumb's Veterinary Drug Handbook, 9th Ed; VECCS Guidelines. Verify against current literature before clinical use.
Binds cyanide to form cyanocobalamin (vitamin B12), which is renally excreted. Direct chemical neutralization of cyanide without methemoglobin formation.
Causes red discoloration of skin, urine, and mucous membranes for days. Interferes with colorimetric lab tests. Very safe compared to sodium nitrite.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
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A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
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