ExoticRx · exoticrx.com/drugs/acetylcysteine-antidotal
Mucomyst, Acetadote
Provides cysteine for hepatic glutathione regeneration, conjugating the toxic NAPQI metabolite of acetaminophen. Also acts as direct free radical scavenger.
IV preferred for severe toxicosis. PO causes vomiting due to taste/smell. Loading dose followed by maintenance. Most effective within 8-10 hours of ingestion.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | IV | 140 mg/kg | Loading 140mg/kg IV, then 70mg/kg q4h x 7 doses | Strong | Plumb's Veterinary Drug Handbook, 9th Ed; ASPCA Toxicology |
| Cat (Domestic) | IV | 140 mg/kg | Loading 140mg/kg IV, then 70mg/kg q6h x 5-7 doses | Strong | Plumb's Veterinary Drug Handbook, 9th Ed; ASPCA Toxicology |
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