ExoticRx · exoticrx.com/drugs/acetylcysteine-antidotal
Acetylcysteine (Antidotal)
Mucomyst, Acetadote
Drug Class
Routes
Indications
Mechanism of Action
Provides cysteine for hepatic glutathione regeneration, conjugating the toxic NAPQI metabolite of acetaminophen. Also acts as direct free radical scavenger.
Side effects & warnings
IV preferred for severe toxicosis. PO causes vomiting due to taste/smell. Loading dose followed by maintenance. Most effective within 8-10 hours of ingestion.
Species with Acetylcysteine (Antidotal) dosing data (2 dose rules)
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
Evidence levels across 2 dose rules
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
Backed by a published source
- · Plumb's Veterinary Drug Handbook, 9th Ed; ASPCA Toxicology
Sample dosing (2 of 2 cited rules)
A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | IV | 140 mg/kg | Loading 140mg/kg IV, then 70mg/kg q4h x 7 doses | Strong | Plumb's Veterinary Drug Handbook, 9th Ed; ASPCA Toxicology |
| Cat (Domestic) | IV | 140 mg/kg | Loading 140mg/kg IV, then 70mg/kg q6h x 5-7 doses | Strong | Plumb's Veterinary Drug Handbook, 9th Ed; ASPCA Toxicology |
Upgrade for Full Details
Upgrade to Pro or Student to unlock the full dose ranges and frequency for every species. The drug's mechanism, warnings, indications, and cited sources are free to read.
View PlansOther formulations of Acetylcysteine
More Antidote drugs
Source citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.