Acetylcysteine (Antidotal) for Dog
Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Acetylcysteine (Antidotal) is used in dog for Acetaminophen toxicosis. Routes documented in dog: IV. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Acetylcysteine (Antidotal) in dog, drawn from published veterinary references. Verify against current literature before clinical use.
Trade names: Mucomyst, Acetadote
Dose ranges
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 140 mg/kg | Loading 140mg/kg IV, then 70mg/kg q4h x 7 doses | Loading dose then 7 maintenance doses over 28 hours | Acetaminophen toxicosis | Strong | Plumb's Veterinary Drug Handbook, 9th Ed; ASPCA Toxicology |
Need the exact dose for your patient?
These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Mechanism of action
Provides cysteine for hepatic glutathione regeneration, conjugating the toxic NAPQI metabolite of acetaminophen. Also acts as direct free radical scavenger.
Side effects & warnings
IV preferred for severe toxicosis. PO causes vomiting due to taste/smell. Loading dose followed by maintenance. Most effective within 8-10 hours of ingestion.
Species-specific contraindications and adverse-reaction reports for dog may differ from canine / feline reference data — consult the primary citations listed with each rule.
Other Antidote drugs with dog dosing
Acetylcysteine (Antidotal) dosing in other species
Why a species-specific page? Acetylcysteine (Antidotal) pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dog — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.