Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Acetylcysteine (Antidotal) is dosed at 140 mg/kg IV Loading 140mg/kg IV, then 70mg/kg q4h x 7 doses in dogs, per Papich, Saunders Handbook of Veterinary Drugs, 4th ed. (2016), Acetylcysteine monograph, printed p. 8 (corpus papich p. 36), Small Animal Dosage / Dogs and Cats: 'Antidote: 140 mg/kg (loading dose), then 70 mg/kg q4h IV or PO for 5 doses.'. Acetylcysteine (Antidotal) is used in dogs for Acetaminophen toxicosis. Routes documented in dogs: IV. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Acetylcysteine (Antidotal) in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Mucomyst, Acetadote
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 140 mg/kg | Loading 140mg/kg IV, then 70mg/kg q4h x 7 doses | Loading dose then 7 maintenance doses over 28 hours | Acetaminophen toxicosis | Strong | Papich, Saunders Handbook of Veterinary Drugs, 4th ed. (2016), Acetylcysteine monograph, printed p. 8 (corpus papich p. 36), Small Animal Dosage / Dogs and Cats: 'Antidote: 140 mg/kg (loading dose), then 70 mg/kg q4h IV or PO for 5 doses.' |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Provides cysteine for hepatic glutathione regeneration, conjugating the toxic NAPQI metabolite of acetaminophen. Also acts as direct free radical scavenger.
IV preferred for severe toxicosis. PO causes vomiting due to taste/smell. Loading dose followed by maintenance. Most effective within 8-10 hours of ingestion.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Acetylcysteine (Antidotal) dose range in dogs, with cited source references: IV 140 mg/kg Loading 140mg/kg IV, then 70mg/kg q4h x 7 doses. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Acetylcysteine (Antidotal) in dogs: IV.
Cited course lengths for Acetylcysteine (Antidotal) in dogs include: Loading dose then 7 maintenance doses over 28 hours. Duration depends on the indication — match it to the specific dose rule in the table above.
Acetylcysteine (Antidotal) is indicated in dogs for: Acetaminophen toxicosis.
These are general warnings for Acetylcysteine (Antidotal) across species; consult the dog dosing table above for species-specific guidance. IV preferred for severe toxicosis. PO causes vomiting due to taste/smell. Loading dose followed by maintenance. Most effective within 8-10 hours of ingestion.
Why a species-specific page? Acetylcysteine (Antidotal) pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.