Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Fomepizole (4-MP) is used in dog for Ethylene glycol toxicosis. Routes documented in dog: IV. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Fomepizole (4-MP) in dog, drawn from published veterinary references. Verify against current literature before clinical use.
Trade names: Antizol-Vet
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 20 mg/kg | 20mg/kg load; 15 at 12h,24h; 5 at 36h | 4-dose protocol over 36 hours | Ethylene glycol toxicosis | Strong | Plumb's Veterinary Drug Handbook, 9th Ed; ASPCA Toxicology |
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Competitive inhibitor of alcohol dehydrogenase, preventing metabolism of ethylene glycol to toxic metabolites (glycolaldehyde, glycolic acid, oxalate).
Most effective within 8-12 hours of ethylene glycol ingestion in dogs (3 hours in cats). Cats require higher doses. Very expensive but life-saving.
Species-specific contraindications and adverse-reaction reports for dog may differ from canine / feline reference data — consult the primary citations listed with each rule.
Why a species-specific page? Fomepizole (4-MP) pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dog — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.