Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Fomepizole (4-MP) is dosed at 20 mg/kg IV 20mg/kg load; 15 at 12h,24h; 5 at 36h in dogs, per ANTIZOL-VET - Fomepizole Liquid [US Product Label for Dogs]. Paladin Labs (USA), Inc; 2017. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=c045b5a8-b220-4f0a-a831-155b29c19454 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.585 (2026-08-01).. Fomepizole (4-MP) is used in dogs for Ethylene glycol toxicosis. Routes documented in dogs: IV. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Fomepizole (4-MP) in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Antizol-Vet
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 20 mg/kg | 20mg/kg load; 15 at 12h,24h; 5 at 36h | 4-dose protocol over 36 hours | Ethylene glycol toxicosis | Strong |
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Competitive inhibitor of alcohol dehydrogenase, preventing metabolism of ethylene glycol to toxic metabolites (glycolaldehyde, glycolic acid, oxalate).
Most effective within 8-12 hours of ethylene glycol ingestion in dogs (3 hours in cats). Cats require higher doses. Very expensive but life-saving.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Fomepizole (4-MP) dose range in dogs, with cited source references: IV 20 mg/kg 20mg/kg load; 15 at 12h,24h; 5 at 36h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Fomepizole (4-MP) in dogs: IV.
Cited course lengths for Fomepizole (4-MP) in dogs include: 4-dose protocol over 36 hours. Duration depends on the indication — match it to the specific dose rule in the table above.
Fomepizole (4-MP) is indicated in dogs for: Ethylene glycol toxicosis.
These are general warnings for Fomepizole (4-MP) across species; consult the dog dosing table above for species-specific guidance. Most effective within 8-12 hours of ethylene glycol ingestion in dogs (3 hours in cats). Cats require higher doses. Very expensive but life-saving.
Why a species-specific page? Fomepizole (4-MP) pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.