Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Fomepizole (4-MP) is dosed at 20 mg/kg IV 20mg/kg load; 15 at 12h,24h; 5 at 36h in dogs, per ANTIZOL-VET - Fomepizole Liquid [US Product Label for Dogs]. Paladin Labs (USA), Inc; 2017. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=c045b5a8-b220-4f0a-a831-155b29c19454 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.585 (2026-08-01). — Plumb's 10th ed (held) printed p.558, Fomepizole monograph; page located 2026-08-05 from the book's own running heads, and carries this exact dose under the matching species heading. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Fomepizole (4-MP) is used in dogs for Ethylene glycol toxicosis. Routes documented in dogs: IV. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Fomepizole (4-MP) in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Antizol-Vet
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 20 mg/kg | 20mg/kg load; 15 at 12h,24h; 5 at 36h | 4-dose protocol over 36 hours | Ethylene glycol toxicosis | Strong | ANTIZOL-VET - Fomepizole Liquid [US Product Label for Dogs]. Paladin Labs (USA), Inc; 2017. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=c045b5a8-b220-4f0a-a831-155b29c19454 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.585 (2026-08-01). — Plumb's 10th ed (held) printed p.558, Fomepizole monograph; page located 2026-08-05 from the book's own running heads, and carries this exact dose under the matching species heading. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
The sources disagree for this combination. The ranges below do not overlap on a comparable route. This is not an error in one of them — published veterinary references differ, and reconciling them for a particular patient is a clinical judgement.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 20 | IV | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.191 | 20 mg/kg i.v. infusion over 30 min initially, then 15 mg/kg i.v. slowly over 15-30 min 12 h and 24 |
| 15 | IV | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.191 | 20 mg/kg i.v. infusion over 30 min initially, then 15 mg/kg i.v. slowly over 15-30 min 12 h and 24 h later, then 5 mg/kg i.v. q12h until ethylene gly |
| 5 | IV | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.191 | mg/kg i.v. slowly over 15-30 min 12 h and 24 h later, then 5 mg/kg i.v. q12h until ethylene glycol concentration is negligible or the dog has recovered. Mos |
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Competitive inhibitor of alcohol dehydrogenase, preventing metabolism of ethylene glycol to toxic metabolites (glycolaldehyde, glycolic acid, oxalate).
Most effective within 8-12 hours of ethylene glycol ingestion in dogs (3 hours in cats). Cats require higher doses. Very expensive but life-saving.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Fomepizole (4-MP) dose range in dogs, with cited source references: IV 20 mg/kg 20mg/kg load; 15 at 12h,24h; 5 at 36h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Fomepizole (4-MP) in dogs: IV.
Cited course lengths for Fomepizole (4-MP) in dogs include: 4-dose protocol over 36 hours. Duration depends on the indication — match it to the specific dose rule in the table above.
Fomepizole (4-MP) is indicated in dogs for: Ethylene glycol toxicosis.
These are general warnings for Fomepizole (4-MP) across species; consult the dog dosing table above for species-specific guidance. Most effective within 8-12 hours of ethylene glycol ingestion in dogs (3 hours in cats). Cats require higher doses. Very expensive but life-saving.
Why a species-specific page? Fomepizole (4-MP) pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.
| 20 | IV | Papich Saunders Handbook of Veterinary Drugs, 4th edp.372 | • 20 mg/kg initially IV, then 15 mg/kg at 12- and 24-hour intervals, then 5 mg at |
| 15 | IV | Papich Saunders Handbook of Veterinary Drugs, 4th edp.372 | • 20 mg/kg initially IV, then 15 mg/kg at 12- and 24-hour intervals, then 5 mg at |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.