Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Atipamezole is dosed at If a higher dose of dexmedetomidine was administered, increase this dose accordingly." Published figures, dog and cat: Plumb's 10th ed printed p.107 gives 0.02-0.1 mg/kg IV to effect, or 0.1-0.2 mg/kg IM or slow IV, based on a 10 mcg/kg dexmedetomidine dose in dogs, per Plumb's Veterinary Drug Handbook, 10th ed (2023, held copy; the original seed cited the 9th, which was never consulted) — Plumb's 10th ed (held) printed p.106, Atipamezole monograph spanning p.106-107; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Atipamezole is used in dogs for Medetomidine/dexmedetomidine reversal. Routes documented in dogs: IM. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Atipamezole in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Antisedan
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IM | If a higher dose of dexmedetomidine was administered, increase this dose accordingly." Published figures, dog and cat: Plumb's 10th ed printed p.107 gives 0.02-0.1 mg/kg IV to effect, or 0.1-0.2 mg/kg IM or slow IV, based on a 10 mcg/kg dexmedetomidine dose | Equal volume to medetomidine or 5x dexmedetomidine | Single dose | Medetomidine/dexmedetomidine reversal | Strong | Plumb's Veterinary Drug Handbook, 10th ed (2023, held copy; the original seed cited the 9th, which was never consulted) — Plumb's 10th ed (held) printed p.106, Atipamezole monograph spanning p.106-107; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mcg/kg) | Route | Source | As printed |
|---|---|---|---|
| 25 | IM | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.52 | 25 μg (micrograms)/kg i.m. but if there is no benefit within 30 minutes this can be repeated or increm |
| 200 | — | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.52 | repeated or incrementally increased every 30 minutes up to 200 μg/kg |
| Dose (mg/ml) | Route | Source | As printed |
|---|---|---|---|
| 0.5 | IM | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.52 | dine dose or 10 times the previous dose of dexmedetomidine (0.5 mg/ml solution) i.m. (i.e. equal volume of solution to medetomidine or dexmedetomidine |
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Selective alpha-2 adrenergic antagonist. Specifically reverses sedation, bradycardia, and other effects of medetomidine/dexmedetomidine.
IM route only (IV can cause cardiovascular excitation). Give equal volume to medetomidine or 5x volume of dexmedetomidine. Reversal within 5-10 minutes. May unmask pain.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Atipamezole dose range in dogs, with cited source references: IM If a higher dose of dexmedetomidine was administered, increase this dose accordingly." Published figures, dog and cat: Plumb's 10th ed printed p.107 gives 0.02-0.1 mg/kg IV to effect, or 0.1-0.2 mg/kg IM or slow IV, based on a 10 mcg/kg dexmedetomidine dose Equal volume to medetomidine or 5x dexmedetomidine. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Atipamezole in dogs: IM.
Cited course lengths for Atipamezole in dogs include: Single dose. Duration depends on the indication — match it to the specific dose rule in the table above.
Atipamezole is indicated in dogs for: Medetomidine/dexmedetomidine reversal.
These are general warnings for Atipamezole across species; consult the dog dosing table above for species-specific guidance. IM route only (IV can cause cardiovascular excitation). Give equal volume to medetomidine or 5x volume of dexmedetomidine. Reversal within 5-10 minutes. May unmask pain.
Why a species-specific page? Atipamezole pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.
| 0.5 | IV | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.52 | equal volume of solution to medetomidine or dexmedetomidine 0.5 mg/ml solution given). When medetomidine or dexmedetomidine has been administered at l |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.