Reptile · Eublepharis macularius · typical adult weight 0.04–0.10 kg
Atipamezole is dosed at 0.5 mg/kg SC single dose (reversal) in leopard geckos, per Mason AK, Lee J, Perry SM, Boykin KL, Del Piero F, Lierz M, Mitchell MA. Animals (Basel). 2021 Aug 24;11(9):2477. doi:10.3390/ani11092477. PMCID: PMC8470321. URL: https://pmc.ncbi.nlm.nih.gov/articles/PMC8470321/. Atipamezole is used in leopard geckos for Reversal of dexmedetomidine. Routes documented in leopard geckos: SC. A typical adult leopard gecko weighs 0.04–0.10 kg. ExoticRx lists 1 cited dose rule for Atipamezole in leopard geckos, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Antisedan
| Route | Dose | Frequency | Indication | Evidence | Source |
|---|---|---|---|---|---|
| SC | 0.5 mg/kg | single dose (reversal) | Reversal of dexmedetomidine |
| Mason AK, Lee J, Perry SM, Boykin KL, Del Piero F, Lierz M, Mitchell MA. Animals (Basel). 2021 Aug 24;11(9):2477. doi:10.3390/ani11092477. PMCID: PMC8470321. URL: https://pmc.ncbi.nlm.nih.gov/articles/PMC8470321/ |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 1–3 | IM | Carpenter's Exotic Animal Formulary, 6th edTable 4.5 | 1-3 mg/kg IM |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.
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These ranges are per kg. Enter your leopard gecko's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Selective alpha-2 adrenergic antagonist. Specifically reverses sedation, bradycardia, and other effects of medetomidine/dexmedetomidine.
IM route only (IV can cause cardiovascular excitation). Give equal volume to medetomidine or 5x volume of dexmedetomidine. Reversal within 5-10 minutes. May unmask pain.
Species-specific contraindications and adverse-reaction reports for leopard geckos may differ from canine / feline reference data — consult the primary citations listed with each rule.
Atipamezole dose range in leopard geckos, with cited source references: SC 0.5 mg/kg single dose (reversal). Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Atipamezole in leopard geckos: SC.
Atipamezole is indicated in leopard geckos for: Reversal of dexmedetomidine.
These are general warnings for Atipamezole across species; consult the leopard gecko dosing table above for species-specific guidance. IM route only (IV can cause cardiovascular excitation). Give equal volume to medetomidine or 5x volume of dexmedetomidine. Reversal within 5-10 minutes. May unmask pain.
Why a species-specific page? Atipamezole pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in leopard geckos — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.