Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Edrophonium is dosed at 0.1–0.2 mg/kg IV Single IV test dose in dogs, per Lipsitz D. Chapter 74: Diseases of the Neuromuscular Junction. In: Bruyette DS, ed. Clinical Small Animal Internal Medicine. John Wiley & Sons, Inc.; 2020. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.468 (2026-08-01). — Plumb's 10th ed (held) printed p.441, Edrophonium monograph spanning p.440-441; page located 2026-08-05 from the book's own running heads, and carries this exact dose under the matching species heading. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 — CEILING: Papich printed p.280 — "0.11-0.22 mg/kg IV (maximum dose is 5 mg per dog)."; corroborated by BSAVA printed p.143 — "Diagnosis of myasthenia gravis: 0.1 mg/kg i.v. (maximum 5 mg).". Edrophonium is used in dogs for Myasthenia gravis (diagnostic Tensilon test). Routes documented in dogs: IV. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Edrophonium in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Tensilon, Enlon
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 0.1–0.2 mg/kgmax 5 mg total | Single IV test dose | Single diagnostic dose; observe for 5-10 minutes for clinical improvement | Myasthenia gravis (diagnostic Tensilon test) | Strong | Lipsitz D. Chapter 74: Diseases of the Neuromuscular Junction. In: Bruyette DS, ed. Clinical Small Animal Internal Medicine. John Wiley & Sons, Inc.; 2020. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.468 (2026-08-01). — Plumb's 10th ed (held) printed p.441, Edrophonium monograph spanning p.440-441; page located 2026-08-05 from the book's own running heads, and carries this exact dose under the matching species heading. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 — CEILING: Papich printed p.280 — "0.11-0.22 mg/kg IV (maximum dose is 5 mg per dog)."; corroborated by BSAVA printed p.143 — "Diagnosis of myasthenia gravis: 0.1 mg/kg i.v. (maximum 5 mg)." |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
The sources disagree for this combination. The ranges below do not overlap on a comparable route. This is not an error in one of them — published veterinary references differ, and reconciling them for a particular patient is a clinical judgement.
| Dose (mg/animal) | Route | Source | As printed |
|---|---|---|---|
| 0.25–0.5 | IV | Papich Saunders Handbook of Veterinary Drugs, 4th edp.308 | • 0.11-0.22 mg/kg IV (maximum dose • 0.25-0.5 mg/cat IV. |
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 0.05 | IV | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.159 | tes, for a positive test. Atropine should be available (0.05 mg/kg) to control cholinergic side effects (e.g. salivation, urination). If there is no res |
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Ultra-short-acting reversible acetylcholinesterase inhibitor used diagnostically. Transient improvement in myasthenia gravis confirms the diagnosis.
Very short duration (5-10 minutes). Have atropine ready for cholinergic reactions. False negatives possible. Use IV only with monitoring.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Edrophonium dose range in dogs, with cited source references: IV 0.1–0.2 mg/kg Single IV test dose. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Edrophonium in dogs: IV.
Cited course lengths for Edrophonium in dogs include: Single diagnostic dose; observe for 5-10 minutes for clinical improvement. Duration depends on the indication — match it to the specific dose rule in the table above.
Edrophonium is indicated in dogs for: Myasthenia gravis (diagnostic Tensilon test).
These are general warnings for Edrophonium across species; consult the dog dosing table above for species-specific guidance. Very short duration (5-10 minutes). Have atropine ready for cholinergic reactions. False negatives possible. Use IV only with monitoring.
Why a species-specific page? Edrophonium pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.
| 0.2 |
| IV |
| BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.159 |
| e is no response, repeat test after 10-20 minutes using 0.2 mg/kg. • Atrial tachycardia after failure of vagal manoeuvres: 1.5 mg i.v. once (NB: this |
| 0.5–1 | IV | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.159 | f non-depolarizing neuromuscular blockade: edrophonium (0.5-1.0 mg/kg) is mixed with atropine (0.04 mg/ kg) and injected i.v. over 2 minutes once signs of |
| 0.1 | IV | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.159 | 0.1 mg/kg i.v. (maximum 5 mg). Improvement should be noted within 30 seconds, with the effe |
| 0.5 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.310 | • 0.5 mg/kg q12-24h PO. In some animals it may be necessary to increase dose to |
| 1 | — | Papich Saunders Handbook of Veterinary Drugs, 4th edp.310 | 1 mg/kg per day, administered as 0.5 mg/kg q12h. |
| 0.5 | — | Papich Saunders Handbook of Veterinary Drugs, 4th edp.310 | 1 mg/kg per day, administered as 0.5 mg/kg q12h. |
| 0.11–0.22 | IV | Papich Saunders Handbook of Veterinary Drugs, 4th edp.308 | • 0.11-0.22 mg/kg IV (maximum dose • 0.25-0.5 mg/cat IV. |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.