Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Edrophonium is dosed at 0.1–0.2 mg/kg IV Single IV test dose in dogs, per Lipsitz D. Chapter 74: Diseases of the Neuromuscular Junction. In: Bruyette DS, ed. Clinical Small Animal Internal Medicine. John Wiley & Sons, Inc.; 2020. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.468 (2026-08-01).. Edrophonium is used in dogs for Myasthenia gravis (diagnostic Tensilon test). Routes documented in dogs: IV. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Edrophonium in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Tensilon, Enlon
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 0.1–0.2 mg/kgmax 5 mg total | Single IV test dose | Single diagnostic dose; observe for 5-10 minutes for clinical improvement | Myasthenia gravis (diagnostic Tensilon test) | Strong | Lipsitz D. Chapter 74: Diseases of the Neuromuscular Junction. In: Bruyette DS, ed. Clinical Small Animal Internal Medicine. John Wiley & Sons, Inc.; 2020. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.468 (2026-08-01). |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Ultra-short-acting reversible acetylcholinesterase inhibitor used diagnostically. Transient improvement in myasthenia gravis confirms the diagnosis.
Very short duration (5-10 minutes). Have atropine ready for cholinergic reactions. False negatives possible. Use IV only with monitoring.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Edrophonium dose range in dogs, with cited source references: IV 0.1–0.2 mg/kg Single IV test dose. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Edrophonium in dogs: IV.
Cited course lengths for Edrophonium in dogs include: Single diagnostic dose; observe for 5-10 minutes for clinical improvement. Duration depends on the indication — match it to the specific dose rule in the table above.
Edrophonium is indicated in dogs for: Myasthenia gravis (diagnostic Tensilon test).
These are general warnings for Edrophonium across species; consult the dog dosing table above for species-specific guidance. Very short duration (5-10 minutes). Have atropine ready for cholinergic reactions. False negatives possible. Use IV only with monitoring.
Why a species-specific page? Edrophonium pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.