Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Flumazenil is dosed at 0.01–0.02 mg/kg IV IV bolus in dogs, per Grimm KA, Lamont LA, Tranquilli WJ, Greene SA, Robertson SA. Veterinary Anesthesia and Analgesia: The Fifth Edition of Lumb and Jones. 5th ed. Ames, IA: Wiley-Blackwell; 2015. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.565 (2026-08-01). — Plumb's 10th ed (held) printed p.537, Flumazenil monograph spanning p.537-538; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Flumazenil is used in dogs for Benzodiazepine reversal. Routes documented in dogs: IV. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Flumazenil in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Romazicon
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 0.01–0.02 mg/kg | IV bolus | May repeat in 20 min | Benzodiazepine reversal | Strong | Grimm KA, Lamont LA, Tranquilli WJ, Greene SA, Robertson SA. Veterinary Anesthesia and Analgesia: The Fifth Edition of Lumb and Jones. 5th ed. Ames, IA: Wiley-Blackwell; 2015. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.565 (2026-08-01). — Plumb's 10th ed (held) printed p.537, Flumazenil monograph spanning p.537-538; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mcg/kg) | Route | Source | As printed |
|---|---|---|---|
| 20 | IV | Papich Saunders Handbook of Veterinary Drugs, 4th edp.362 | • 0.02 mg/kg (20 mcg/kg) IV. |
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 0.01–0.1 | IV | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.186 | 0.01-0.1 mg/kg i.v., can be repeated if marked respiratory depression reoccurs. It takes 6-10 minu |
| 0.02 | IV | Papich Saunders Handbook of Veterinary Drugs, 4th edp.362 | • 0.02 mg/kg (20 mcg/kg) IV. |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.
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Competitive benzodiazepine receptor antagonist at GABA-A receptor. Reverses sedation, respiratory depression, and anxiolysis from benzodiazepines.
Short duration (45-60 min) — resedation risk with long-acting benzodiazepines. May precipitate seizures in benzodiazepine-dependent patients or when benzos given for seizure control.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Flumazenil dose range in dogs, with cited source references: IV 0.01–0.02 mg/kg IV bolus. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Flumazenil in dogs: IV.
Cited course lengths for Flumazenil in dogs include: May repeat in 20 min. Duration depends on the indication — match it to the specific dose rule in the table above.
Flumazenil is indicated in dogs for: Benzodiazepine reversal.
These are general warnings for Flumazenil across species; consult the dog dosing table above for species-specific guidance. Short duration (45-60 min) — resedation risk with long-acting benzodiazepines. May precipitate seizures in benzodiazepine-dependent patients or when benzos given for seizure control.
Why a species-specific page? Flumazenil pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.