Pocket Pet · Cavia porcellus · typical adult weight 0.70–1.20 kg
Atipamezole is dosed at If a higher dose of dexmedetomidine was administered, increase this dose accordingly." Published figure, guinea pig: Plumb's 10th ed printed p.107, "Mice, Rats, Chinchillas, Gerbils, Hamsters, Guinea pigs: reversal of xylazine or medetomidine (extra-label): 0.1 - 1 mg/kg IM, IP, IV, or SC" in guinea pigs, per Meredith A. BSAVA Small Animal Formulary: Part B: Exotic Pets, British Small Animal Veterinary Association, Quedgeley, Gloucester, UK; 2015. — Verified against Carpenter's Exotic Animal Formulary, 6th Ed, p.783 (2026-08-01). — Carpenter's Exotic Animal Formulary 6th ed, Table 9.3 (Chemical Restraint/Anesthetic Agents Used in Rodents). The copy held is an ebook conversion with no printed page numbers, so the table — not the page — is the citable location. — SOURCE EDITION: BSAVA Small Animal Formulary, Part B — Exotic Pets — ISBN 9781910443712, https://openlibrary.org/isbn/9781910443712; Carpenter's Exotic Animal Formulary — ISBN 9780323833929, https://openlibrary.org/isbn/9780323833929. Atipamezole is used in guinea pigs for Medetomidine/dexmedetomidine reversal. Routes documented in guinea pigs: SC, IM. A typical adult guinea pig weighs 0.70–1.20 kg. ExoticRx lists 1 cited dose rule for Atipamezole in guinea pigs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Antisedan
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|
| SC, IM | If a higher dose of dexmedetomidine was administered, increase this dose accordingly." Published figure, guinea pig: Plumb's 10th ed printed p.107, "Mice, Rats, Chinchillas, Gerbils, Hamsters, Guinea pigs: reversal of xylazine or medetomidine (extra-label): 0.1 - 1 mg/kg IM, IP, IV, or SC" | Equal volume to medetomidine | Single dose | Medetomidine/dexmedetomidine reversal | Moderate | Meredith A. BSAVA Small Animal Formulary: Part B: Exotic Pets, British Small Animal Veterinary Association, Quedgeley, Gloucester, UK; 2015. — Verified against Carpenter's Exotic Animal Formulary, 6th Ed, p.783 (2026-08-01). — Carpenter's Exotic Animal Formulary 6th ed, Table 9.3 (Chemical Restraint/Anesthetic Agents Used in Rodents). The copy held is an ebook conversion with no printed page numbers, so the table — not the page — is the citable location. — SOURCE EDITION: BSAVA Small Animal Formulary, Part B — Exotic Pets — ISBN 9781910443712, https://openlibrary.org/isbn/9781910443712; Carpenter's Exotic Animal Formulary — ISBN 9780323833929, https://openlibrary.org/isbn/9780323833929 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 0.15 | IM | Carpenter's Exotic Animal Formulary, 6th edTable 9.3 | 0.15 mg/kg IM |
| 1 | SC | Carpenter's Exotic Animal Formulary, 6th edTable 9.3 | 1 mg/kg SC |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.
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Selective alpha-2 adrenergic antagonist. Specifically reverses sedation, bradycardia, and other effects of medetomidine/dexmedetomidine.
IM route only (IV can cause cardiovascular excitation). Give equal volume to medetomidine or 5x volume of dexmedetomidine. Reversal within 5-10 minutes. May unmask pain.
Species-specific contraindications and adverse-reaction reports for guinea pigs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Atipamezole dose range in guinea pigs, with cited source references: SC, IM If a higher dose of dexmedetomidine was administered, increase this dose accordingly." Published figure, guinea pig: Plumb's 10th ed printed p.107, "Mice, Rats, Chinchillas, Gerbils, Hamsters, Guinea pigs: reversal of xylazine or medetomidine (extra-label): 0.1 - 1 mg/kg IM, IP, IV, or SC" Equal volume to medetomidine. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Atipamezole in guinea pigs: SC, IM.
Cited course lengths for Atipamezole in guinea pigs include: Single dose. Duration depends on the indication — match it to the specific dose rule in the table above.
Atipamezole is indicated in guinea pigs for: Medetomidine/dexmedetomidine reversal.
These are general warnings for Atipamezole across species; consult the guinea pig dosing table above for species-specific guidance. IM route only (IV can cause cardiovascular excitation). Give equal volume to medetomidine or 5x volume of dexmedetomidine. Reversal within 5-10 minutes. May unmask pain.
Why a species-specific page? Atipamezole pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in guinea pigs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.