Pocket Pet · Mus musculus · typical adult weight 0.02–0.04 kg
Atipamezole is dosed at 1 mg/kg IP once, 30 min after ketamine-xylazine induction in mice, per Beecy S, Meuse D, Kizielewicz N, Beale C, Molk D. Optimization of Ketamine/Xylazine Anesthesia in Geriatric Mice. J Am Assoc Lab Anim Sci. 2025;64(4):778-787. doi:10.30802/AALAS-JAALAS-25-010. PMID 40683626. https://pmc.ncbi.nlm.nih.gov/articles/PMC12530262/. Atipamezole is used in mice for Reversal of xylazine (alpha-2 antagonist) after injectable anaesthesia, Alpha-2 agonist (medetomidine/dexmedetomidine) reversal. Routes documented in mice: IP, SC. A typical adult mouse weighs 0.02–0.04 kg. ExoticRx lists 2 cited dose rules for Atipamezole in mice, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Antisedan
| Route | Dose | Frequency | Indication | Evidence | Source |
|---|---|---|---|---|---|
| IP | 1 mg/kg | once, 30 min after ketamine-xylazine induction | Reversal of xylazine (alpha-2 antagonist) after injectable anaesthesia | Moderate | Beecy S, Meuse D, Kizielewicz N, Beale C, Molk D. Optimization of Ketamine/Xylazine Anesthesia in Geriatric Mice. J Am Assoc Lab Anim Sci. 2025;64(4):778-787. doi:10.30802/AALAS-JAALAS-25-010. PMID 40683626. https://pmc.ncbi.nlm.nih.gov/articles/PMC12530262/ |
| SC | 1 mg/kg | once (reversal) | Alpha-2 agonist (medetomidine/dexmedetomidine) reversal | Moderate | 130. Morrisey JK, Carpenter JW. Formulary. In: Quesenberry KE, Carpenter JW, eds. Ferrets, Rabbits, and Rodents: Clinical Medicine and Surgery, 4th ed., Elsevier, St. Louis, MO; 2021:620-630. — Mined from Carpenter's Exotic Animal Formulary, 6th Ed, p.783 (2026-08-01, PENDING REVIEW) |
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Selective alpha-2 adrenergic antagonist. Specifically reverses sedation, bradycardia, and other effects of medetomidine/dexmedetomidine.
IM route only (IV can cause cardiovascular excitation). Give equal volume to medetomidine or 5x volume of dexmedetomidine. Reversal within 5-10 minutes. May unmask pain.
Species-specific contraindications and adverse-reaction reports for mice may differ from canine / feline reference data — consult the primary citations listed with each rule.
Atipamezole dose ranges in mice, with cited source references: IP 1 mg/kg once, 30 min after ketamine-xylazine induction; SC 1 mg/kg once (reversal). Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Atipamezole in mice: IP, SC.
Atipamezole is indicated in mice for: Reversal of xylazine (alpha-2 antagonist) after injectable anaesthesia, Alpha-2 agonist (medetomidine/dexmedetomidine) reversal.
These are general warnings for Atipamezole across species; consult the mouse dosing table above for species-specific guidance. IM route only (IV can cause cardiovascular excitation). Give equal volume to medetomidine or 5x volume of dexmedetomidine. Reversal within 5-10 minutes. May unmask pain.
Why a species-specific page? Atipamezole pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in mice — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.