Pocket Pet · Mus musculus · typical adult weight 0.02–0.04 kg
Atipamezole is dosed at 1 mg/kg IP once, 30 min after ketamine-xylazine induction in mice, per Beecy S, Meuse D, Kizielewicz N, Beale C, Molk D. Optimization of Ketamine/Xylazine Anesthesia in Geriatric Mice. J Am Assoc Lab Anim Sci. 2025;64(4):778-787. doi:10.30802/AALAS-JAALAS-25-010. PMID 40683626. https://pmc.ncbi.nlm.nih.gov/articles/PMC12530262/. Atipamezole is used in mice for Reversal of xylazine (alpha-2 antagonist) after injectable anaesthesia, Alpha-2 agonist (medetomidine/dexmedetomidine) reversal. Routes documented in mice: IP, SC. A typical adult mouse weighs 0.02–0.04 kg. ExoticRx lists 2 cited dose rules for Atipamezole in mice, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Antisedan
| Route | Dose | Frequency | Indication | Evidence | Source |
|---|---|---|---|---|---|
| IP | 1 mg/kg | once, 30 min after ketamine-xylazine induction | Reversal of xylazine (alpha-2 antagonist) after injectable anaesthesia | Moderate | Beecy S, Meuse D, Kizielewicz N, Beale C, Molk D. Optimization of Ketamine/Xylazine Anesthesia in Geriatric Mice. J Am Assoc Lab Anim Sci. 2025;64(4):778-787. doi:10.30802/AALAS-JAALAS-25-010. PMID 40683626. https://pmc.ncbi.nlm.nih.gov/articles/PMC12530262/ |
| SC | 1 mg/kg | once (reversal) | Alpha-2 agonist (medetomidine/dexmedetomidine) reversal | Moderate | 130. Morrisey JK, Carpenter JW. Formulary. In: Quesenberry KE, Carpenter JW, eds. Ferrets, Rabbits, and Rodents: Clinical Medicine and Surgery, 4th ed., Elsevier, St. Louis, MO; 2021:620-630. — Source: Carpenter's Exotic Animal Formulary, 6th Ed, p.783 — Carpenter's Exotic Animal Formulary 6th ed, Table 9.3 (Chemical Restraint/Anesthetic Agents Used in Rodents). Located 2026-08-05: the only table covering this species in which the drug's own row prints this dose. The copy held is an ebook conversion with no printed page numbers, so the table is the citable location. — CORROBORATED 2026-08-06 by independent literature: General Anesthesia Induced by a Combination of Medetomidine/Vatinoxan with Ketamine and Buprenorphine-ER in C57BL/6J Mice (Mus musculus). (Journal of the American Association for Laboratory Animal Science : JAALAS, 2024). doi:10.30802/aalas-jaalas-23-000120. https://doi.org/10.30802/aalas-jaalas-23-000120. The paper reports this drug at this dose in this species: "l blood pressure, body temperature, jaw tone, and skin color were monitored every 5 min. Thirty […]". This is a second source alongside the book already cited; it corroborates the figure and does not by itself establish that the dose is correct. — SOURCE EDITION: Carpenter's Exotic Animal Formulary — ISBN 9780323833929, https://openlibrary.org/isbn/9780323833929; Ferrets, Rabbits, and Rodents: Clinical Medicine and Surgery — ISBN 9780323484350, https://openlibrary.org/isbn/9780323484350 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 0.15 | IM | Carpenter's Exotic Animal Formulary, 6th edTable 9.3 | 0.15 mg/kg IM |
| 1 | SC | Carpenter's Exotic Animal Formulary, 6th edTable 9.3 | 1 mg/kg SC |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.
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Selective alpha-2 adrenergic antagonist. Specifically reverses sedation, bradycardia, and other effects of medetomidine/dexmedetomidine.
IM route only (IV can cause cardiovascular excitation). Give equal volume to medetomidine or 5x volume of dexmedetomidine. Reversal within 5-10 minutes. May unmask pain.
Species-specific contraindications and adverse-reaction reports for mice may differ from canine / feline reference data — consult the primary citations listed with each rule.
Atipamezole dose ranges in mice, with cited source references: IP 1 mg/kg once, 30 min after ketamine-xylazine induction; SC 1 mg/kg once (reversal). Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Atipamezole in mice: IP, SC.
Atipamezole is indicated in mice for: Reversal of xylazine (alpha-2 antagonist) after injectable anaesthesia, Alpha-2 agonist (medetomidine/dexmedetomidine) reversal.
These are general warnings for Atipamezole across species; consult the mouse dosing table above for species-specific guidance. IM route only (IV can cause cardiovascular excitation). Give equal volume to medetomidine or 5x volume of dexmedetomidine. Reversal within 5-10 minutes. May unmask pain.
Why a species-specific page? Atipamezole pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in mice — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.