Pocket Pet · Mus musculus · typical adult weight 0.02–0.04 kg
Yohimbine is dosed at 0.5–1 mg/kg IV, IP once (reversal) in mice, per 66. Harkness JE. A Practitioner's Guide to Domestic Rodents, American Animal Hospital Association, Lakewood, CO; 1993. — Mined from Carpenter's Exotic Animal Formulary, 6th Ed, p.788 (2026-08-01, PENDING REVIEW). Yohimbine is used in mice for Xylazine reversal. Routes documented in mice: IV, IP. A typical adult mouse weighs 0.02–0.04 kg. ExoticRx lists 1 cited dose rule for Yohimbine in mice, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Yobine
| Route | Dose | Frequency | Indication | Evidence | Source |
|---|---|---|---|---|---|
| IV, IP | 0.5–1 mg/kg | once (reversal) | Xylazine reversal | Moderate | 66. Harkness JE. A Practitioner's Guide to Domestic Rodents, American Animal Hospital Association, Lakewood, CO; 1993. — Mined from Carpenter's Exotic Animal Formulary, 6th Ed, p.788 (2026-08-01, PENDING REVIEW) |
Need the exact dose for your patient?
These ranges are per kg. Enter your mouse's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Alpha-2 adrenergic antagonist reversing sedation from xylazine and other alpha-2 agonists. Less selective than atipamezole.
Primarily used to reverse xylazine sedation. Less selective than atipamezole (also blocks alpha-1). Tremors, excitation, seizures at high doses. IV route preferred.
Species-specific contraindications and adverse-reaction reports for mice may differ from canine / feline reference data — consult the primary citations listed with each rule.
Yohimbine dose range in mice, with cited source references: IV, IP 0.5–1 mg/kg once (reversal). Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Yohimbine in mice: IV, IP.
Yohimbine is indicated in mice for: Xylazine reversal.
These are general warnings for Yohimbine across species; consult the mouse dosing table above for species-specific guidance. Primarily used to reverse xylazine sedation. Less selective than atipamezole (also blocks alpha-1). Tremors, excitation, seizures at high doses. IV route preferred.
Why a species-specific page? Yohimbine pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in mice — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.