Pocket Pet · Cavia porcellus · typical adult weight 0.70–1.20 kg
Yohimbine is dosed at 0.5–1 mg/kg IV, IP not stated in source in guinea pigs, per Harkness JE. A Practitioner's Guide to Domestic Rodents, American Animal Hospital Association, Lakewood, CO; 1993. — Source: Carpenter's Exotic Animal Formulary, 6th Ed, p.788 — Carpenter's Exotic Animal Formulary 6th ed, Table 9.3 (Chemical Restraint/Anesthetic Agents Used in Rodents). The copy held is an ebook conversion with no printed page numbers, so the table — not the page — is the citable location. — SOURCE EDITION: Carpenter's Exotic Animal Formulary — ISBN 9780323833929, https://openlibrary.org/isbn/9780323833929. Yohimbine is used in guinea pigs for Xylazine reversal. Routes documented in guinea pigs: IV, IP. A typical adult guinea pig weighs 0.70–1.20 kg. ExoticRx lists 1 cited dose rule for Yohimbine in guinea pigs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Yobine
| Route | Dose | Frequency | Indication | Evidence | Source |
|---|---|---|---|---|---|
| IV, IP | 0.5–1 mg/kg | not stated in source | Xylazine reversal | Moderate |
| Harkness JE. A Practitioner's Guide to Domestic Rodents, American Animal Hospital Association, Lakewood, CO; 1993. — Source: Carpenter's Exotic Animal Formulary, 6th Ed, p.788 — Carpenter's Exotic Animal Formulary 6th ed, Table 9.3 (Chemical Restraint/Anesthetic Agents Used in Rodents). The copy held is an ebook conversion with no printed page numbers, so the table — not the page — is the citable location. — SOURCE EDITION: Carpenter's Exotic Animal Formulary — ISBN 9780323833929, https://openlibrary.org/isbn/9780323833929 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 0.5–1 | IV | Carpenter's Exotic Animal Formulary, 6th edTable 9.3 | 0.5-1 mg/kg IV, IP |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.
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Alpha-2 adrenergic antagonist reversing sedation from xylazine and other alpha-2 agonists. Less selective than atipamezole.
Primarily used to reverse xylazine sedation. Less selective than atipamezole (also blocks alpha-1). Tremors, excitation, seizures at high doses. IV route preferred.
Species-specific contraindications and adverse-reaction reports for guinea pigs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Yohimbine dose range in guinea pigs, with cited source references: IV, IP 0.5–1 mg/kg not stated in source. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Yohimbine in guinea pigs: IV, IP.
Yohimbine is indicated in guinea pigs for: Xylazine reversal.
These are general warnings for Yohimbine across species; consult the guinea pig dosing table above for species-specific guidance. Primarily used to reverse xylazine sedation. Less selective than atipamezole (also blocks alpha-1). Tremors, excitation, seizures at high doses. IV route preferred.
Why a species-specific page? Yohimbine pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in guinea pigs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.