Pocket Pet · Cavia porcellus · typical adult weight 0.70–1.20 kg
Yohimbine is dosed at 0.5–1 mg/kg IV, IP not stated in source in guinea pigs, per Harkness JE. A Practitioner's Guide to Domestic Rodents, American Animal Hospital Association, Lakewood, CO; 1993. — Mined from Carpenter's Exotic Animal Formulary, 6th Ed, p.788 (2026-08-01, PENDING REVIEW). Yohimbine is used in guinea pigs for Xylazine reversal. Routes documented in guinea pigs: IV, IP. A typical adult guinea pig weighs 0.70–1.20 kg. ExoticRx lists 1 cited dose rule for Yohimbine in guinea pigs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Yobine
| Route | Dose | Frequency | Indication | Evidence | Source |
|---|---|---|---|---|---|
| IV, IP | 0.5–1 mg/kg | not stated in source | Xylazine reversal | Moderate | Harkness JE. A Practitioner's Guide to Domestic Rodents, American Animal Hospital Association, Lakewood, CO; 1993. — Mined from Carpenter's Exotic Animal Formulary, 6th Ed, p.788 (2026-08-01, PENDING REVIEW) |
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These ranges are per kg. Enter your guinea pig's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Alpha-2 adrenergic antagonist reversing sedation from xylazine and other alpha-2 agonists. Less selective than atipamezole.
Primarily used to reverse xylazine sedation. Less selective than atipamezole (also blocks alpha-1). Tremors, excitation, seizures at high doses. IV route preferred.
Species-specific contraindications and adverse-reaction reports for guinea pigs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Yohimbine dose range in guinea pigs, with cited source references: IV, IP 0.5–1 mg/kg not stated in source. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Yohimbine in guinea pigs: IV, IP.
Yohimbine is indicated in guinea pigs for: Xylazine reversal.
These are general warnings for Yohimbine across species; consult the guinea pig dosing table above for species-specific guidance. Primarily used to reverse xylazine sedation. Less selective than atipamezole (also blocks alpha-1). Tremors, excitation, seizures at high doses. IV route preferred.
Why a species-specific page? Yohimbine pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in guinea pigs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.