Pocket Pet · Rattus norvegicus var. domestica · typical adult weight 0.25–0.70 kg
Atipamezole is dosed at 0.1–1 mg/kg IM, SC, IV, IP once in pet rats, per Plumb's Veterinary Drug Handbook — Atipamezole, p.107 (corpus plumb p.134), RABBITS/RODENTS/SMALL MAMMALS: "Mice, Rats, Chinchillas, Gerbils, Hamsters, Guinea pigs: reversal of xylazine or medetomidine […]"; ceiling corroborated by Carpenter p.783 ("1 mg/kg SC | All species") and frr Table A.4, p.626 (corpus frr p.638) ("Atipamezole ... Rats/Mice 1 mg/kg SC, IM, IV, IP") — Carpenter's Exotic Animal Formulary 6th ed, Table 9.3 (Chemical Restraint/Anesthetic Agents Used in Rodents). The copy held is an ebook conversion with no printed page numbers, so the table — not the page — is the citable location. — LOCATOR CONVENTION 2026-08-07: 'p.107' is the PRINTED page number, confirmed by finding the drug named on it in the held copy. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207; Carpenter's Exotic Animal Formulary — ISBN 9780323833929, https://openlibrary.org/isbn/9780323833929. Atipamezole is used in pet rats for Xylazine reversal. Routes documented in pet rats: IM, SC, IV, IP. A typical adult pet rat weighs 0.25–0.70 kg. ExoticRx lists 1 cited dose rule for Atipamezole in pet rats, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Antisedan
| Route | Dose | Frequency | Indication | Evidence | Source |
|---|---|---|---|---|---|
| IM, SC, IV, IP |
| 0.1–1 mg/kg |
| once |
| Xylazine reversal |
| Weak |
| Plumb's Veterinary Drug Handbook — Atipamezole, p.107 (corpus plumb p.134), RABBITS/RODENTS/SMALL MAMMALS: "Mice, Rats, Chinchillas, Gerbils, Hamsters, Guinea pigs: reversal of xylazine or medetomidine […]"; ceiling corroborated by Carpenter p.783 ("1 mg/kg SC | All species") and frr Table A.4, p.626 (corpus frr p.638) ("Atipamezole ... Rats/Mice 1 mg/kg SC, IM, IV, IP") — Carpenter's Exotic Animal Formulary 6th ed, Table 9.3 (Chemical Restraint/Anesthetic Agents Used in Rodents). The copy held is an ebook conversion with no printed page numbers, so the table — not the page — is the citable location. — LOCATOR CONVENTION 2026-08-07: 'p.107' is the PRINTED page number, confirmed by finding the drug named on it in the held copy. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207; Carpenter's Exotic Animal Formulary — ISBN 9780323833929, https://openlibrary.org/isbn/9780323833929 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 0.15 | IM | Carpenter's Exotic Animal Formulary, 6th edTable 9.3 | 0.15 mg/kg IM |
| 1 | SC | Carpenter's Exotic Animal Formulary, 6th edTable 9.3 | 1 mg/kg SC |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.
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These ranges are per kg. Enter your pet rat's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Selective alpha-2 adrenergic antagonist. Specifically reverses sedation, bradycardia, and other effects of medetomidine/dexmedetomidine.
IM route only (IV can cause cardiovascular excitation). Give equal volume to medetomidine or 5x volume of dexmedetomidine. Reversal within 5-10 minutes. May unmask pain.
Species-specific contraindications and adverse-reaction reports for pet rats may differ from canine / feline reference data — consult the primary citations listed with each rule.
Atipamezole dose range in pet rats, with cited source references: IM, SC, IV, IP 0.1–1 mg/kg once. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Atipamezole in pet rats: IM, SC, IV, IP.
Atipamezole is indicated in pet rats for: Xylazine reversal.
These are general warnings for Atipamezole across species; consult the pet rat dosing table above for species-specific guidance. IM route only (IV can cause cardiovascular excitation). Give equal volume to medetomidine or 5x volume of dexmedetomidine. Reversal within 5-10 minutes. May unmask pain.
Why a species-specific page? Atipamezole pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in pet rats — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.