ExoticRx · exoticrx.com/drugs/iclaprim
US brand names:Motif
Iclaprim is dosed at 0.8–1 mg/kg IV q12h in cats, per Plumb's Veterinary Drug Handbook, 9th Ed. Verify against current literature before clinical use.
Inhibits dihydrofolate reductase (DHFR) with high affinity for trimethoprim-resistant DHFR variants. Active against MRSA.
QTc prolongation risk. Hepatotoxicity monitored in trials. Not yet widely available. No veterinary data.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.