What is Indoxacarb used for?

Indoxacarb is indicated for: Flea control.

Which species have cited Indoxacarb dosing data?

Indoxacarb dosing in the ExoticRx formulary covers 2 species: Cat (Domestic), Dog (Domestic).

Is Indoxacarb a controlled substance?

Indoxacarb is not federally scheduled in the US. Controlled-drug status differs by country — verify your local rules.

Indoxacarb

US brand names:Activyl

Calculate dosage

Sourced from published veterinary references. Awaiting credentialed clinical reviewer — our editorial process.

Drug Class

Antiparasitic

Routes

TOPICAL

Indications

Flea control

Mechanism of Action

Bioactivated by flea enzymes to its active metabolite, which blocks sodium channels causing paralysis and death. Flea-activated (low mammalian toxicity).

Side effects & warnings

Dogs and cats. Monthly topical. Safe for puppies/kittens >8 weeks. May take 8 hours for full flea kill. Lower environmental flea burden important.

Evidence levels across 2 dose rules

Moderate×2

Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.

Backed by 2 published sources

· BSAVA Small Animal Formulary, 10th Ed (2020), Part A — Canine and Feline, p.223-224 — Indoxacarb (Activyl), DOSES, Cats. — LOCATOR CONVENTION 2026-08-07: the bare 'p.223' in this citation is the PDF index of the held scan, not the printed page. The PRINTED page is p.207; verified by finding the drug named there. If you are holding the book, turn to p.207. — SOURCE EDITION: BSAVA Small Animal Formulary, Part A — Canine and Feline — ISBN 9781910443705, https://openlibrary.org/isbn/9781910443705
· BSAVA Small Animal Formulary, 10th Ed (2020), Part A — Canine and Feline, p.223-224 — Indoxacarb (Activyl, Activyl Tick Plus), DOSES, Dogs. — LOCATOR CONVENTION 2026-08-07: the bare 'p.223' in this citation is the PDF index of the held scan, not the printed page. The PRINTED page is p.207; verified by finding the drug named there. If you are holding the book, turn to p.207. — SOURCE EDITION: BSAVA Small Animal Formulary, Part A — Canine and Feline — ISBN 9781910443705, https://openlibrary.org/isbn/9781910443705

Sample dosing (2 of 2 cited rules)

A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.

Species	Route	Dose	Frequency	Evidence	Source
Cat (Domestic)	TOPICAL	See the cited source for the printed regimen	q30 days	Moderate	BSAVA Small Animal Formulary, 10th Ed (2020), Part A — Canine and Feline, p.223-224 — Indoxacarb (Activyl), DOSES, Cats. — LOCATOR CONVENTION 2026-08-07: the bare 'p.223' in this citation is the PDF index of the held scan, not the printed page. The PRINTED page is p.207; verified by finding the drug named there. If you are holding the book, turn to p.207. — SOURCE EDITION: BSAVA Small Animal Formulary, Part A — Canine and Feline — ISBN 9781910443705, https://openlibrary.org/isbn/9781910443705
Dog (Domestic)	TOPICAL	/ Cats: Fleas: 25 mg/kg (equivalent to 0.128 ml/kg Activyl)	q30 days	Moderate	BSAVA Small Animal Formulary, 10th Ed (2020), Part A — Canine and Feline, p.223-224 — Indoxacarb (Activyl, Activyl Tick Plus), DOSES, Dogs. — LOCATOR CONVENTION 2026-08-07: the bare 'p.223' in this citation is the PDF index of the held scan, not the printed page. The PRINTED page is p.207; verified by finding the drug named there. If you are holding the book, turn to p.207. — SOURCE EDITION: BSAVA Small Animal Formulary, Part A — Canine and Feline — ISBN 9781910443705,

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