ExoticRx · exoticrx.com/drugs/indoxacarb
US brand names:Activyl
Bioactivated by flea enzymes to its active metabolite, which blocks sodium channels causing paralysis and death. Flea-activated (low mammalian toxicity).
Dogs and cats. Monthly topical. Safe for puppies/kittens >8 weeks. May take 8 hours for full flea kill. Lower environmental flea burden important.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Cat (Domestic) | TOPICAL | See the cited source for the printed regimen | q30 days | Moderate | BSAVA Small Animal Formulary, 10th Ed (2020), Part A — Canine and Feline, p.207-224 — Indoxacarb (Activyl), DOSES, Cats.Compilation only — we have not located an independent source that prints this figure. |
| Dog (Domestic) | TOPICAL | Bioactivated by flea enzymes — low mammalian toxicity | q30 days | Moderate | BSAVA Small Animal Formulary, 10th Ed (2020), Part A — Canine and Feline, p.207-224 — Indoxacarb (Activyl, Activyl Tick Plus), DOSES, Dogs.Compilation only — we have not located an independent source that prints this figure. |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.