Amphibian · Ambystoma mexicanum · typical adult weight 0.04–0.19 kg
Itraconazole is dosed at 0.002–0.0025 % itraconazole solution (immersion bath) Immersion (bath) once daily for 10 consecutive days in axolotls, per Del Valle JM, Eisthen HL. Treatment of Chytridiomycosis in Laboratory Axolotls (Ambystoma mexicanum) and Rough-skinned Newts (Taricha granulosa). Comp Med. 2019;69(3):204-211. Itraconazole is used in axolotls for Chytridiomycosis (Batrachochytrium dendrobatidis) of the skin. Routes documented in axolotls: Immersion (bath). A typical adult axolotl weighs 0.04–0.19 kg. ExoticRx lists 1 cited dose rule for Itraconazole in axolotls, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Sporanox, Itrafungol
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| Immersion (bath) | 0.002–0.0025 % itraconazole solution (immersion bath) | once daily for 10 consecutive days | Contact time 5 minutes per bath, once daily for 10 consecutive days. Drug diluted in Holtfreter solution (the axolotl's normal isosmotic aquatic medium), not plain water. Follow-up swabs negative at 7 d and 28 d after the last treatment, and again at 6 months. | Chytridiomycosis (Batrachochytrium dendrobatidis) of the skin |
| Del Valle JM, Eisthen HL. Treatment of Chytridiomycosis in Laboratory Axolotls (Ambystoma mexicanum) and Rough-skinned Newts (Taricha granulosa). Comp Med. 2019;69(3):204-211. doi:10.30802/aalas-cm-18-000090 https://pmc.ncbi.nlm.nih.gov/articles/PMC6591673/ |
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Enter your axolotl's weight to check these cited ranges in the calculator — unit and concentration math done for you.
Inhibits fungal 14-alpha-demethylase, blocking ergosterol synthesis. Lipophilic with high tissue concentrations.
Hepatotoxic: monitor liver enzymes. Requires acid pH for capsule absorption (give with food). Negative inotropic effect — avoid in animals with heart failure. CYP3A4 inhibitor.
Species-specific contraindications and adverse-reaction reports for axolotls may differ from canine / feline reference data — consult the primary citations listed with each rule.
Itraconazole dose range in axolotls, with cited source references: Immersion (bath) 0.002–0.0025 % itraconazole solution (immersion bath) once daily for 10 consecutive days. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Itraconazole in axolotls: Immersion (bath).
Cited course lengths for Itraconazole in axolotls include: Contact time 5 minutes per bath, once daily for 10 consecutive days. Drug diluted in Holtfreter solution (the axolotl's normal isosmotic aquatic medium), not plain water. Follow-up swabs negative at 7 d and 28 d after the last treatment, and again at 6 months.. Duration depends on the indication — match it to the specific dose rule in the table above.
Itraconazole is indicated in axolotls for: Chytridiomycosis (Batrachochytrium dendrobatidis) of the skin.
These are general warnings for Itraconazole across species; consult the axolotl dosing table above for species-specific guidance. Hepatotoxic: monitor liver enzymes. Requires acid pH for capsule absorption (give with food). Negative inotropic effect — avoid in animals with heart failure. CYP3A4 inhibitor.
Why a species-specific page? Itraconazole pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in axolotls — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.