ExoticRx · exoticrx.com/drugs/itraconazole
US brand names:Sporanox, Itrafungol
Itraconazole is dosed at 5–10 mg/kg PO q24-48h in ball pythons, per Martel A, Hellebuyck T, Van Waeyenberghe L. Treatment of infections with Nannizziopsis vriesii, an emergent reptilian dermatophyte. Proc Annu Conf Assoc Rept Amph Vet; 2009:69-70.; Mitchell M. Ophidia. In: Fowler ME, Miller RE, eds. Zoo and Wild Animal Medicine, 5th ed., Saunders/Elsevier, Philadelphia, PA; 2003:82-91. — Verified against Carpenter's Exotic Animal Formulary, 6th Ed, p.222 (2026-08-01). — Carpenter's Exotic Animal Formulary 6th ed, Table 4.3 (Antifungal Agents Used in Reptiles). The copy held is an ebook conversion with no printed page numbers, so the table — not the page — is the citable location. — SOURCE EDITION: Carpenter's Exotic Animal Formulary — ISBN 9780323833929, https://openlibrary.org/isbn/9780323833929; Fowler's Zoo and Wild Animal Medicine: Current Therapy — ISBN 9780323828529, https://openlibrary.org/isbn/9780323828529. Verify against current literature before clinical use.
Inhibits fungal 14-alpha-demethylase, blocking ergosterol synthesis. Lipophilic with high tissue concentrations.
Hepatotoxic: monitor liver enzymes. Requires acid pH for capsule absorption (give with food). Negative inotropic effect — avoid in animals with heart failure. CYP3A4 inhibitor.
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 34 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Cat (Domestic) | PO | 5 mg/kg | q24h | Strong | Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.734 (2026-08-01). — Plumb's 10th ed (held) printed p.704, Itraconazole monograph spanning p.704-708; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
| Dog (Domestic) | PO | 5–10 mg/kg | q12h | Strong | Plumb's Veterinary Drug Handbook, 10th ed (2023, held copy; the original seed cited the 9th, which was never consulted) — Plumb's 10th ed (held) printed p.707, Itraconazole monograph spanning p.704-708; page located 2026-08-05 from the book's own running heads, and carries this exact dose under the matching species heading. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, |
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Species references:All African Grey Parrot drugsAll African Pygmy Hedgehog drugsAll Amazon Parrot drugsAll Ball Python drugsAll Bearded Dragon drugsAll Betta (Siamese fighting fish) drugsAll Blue-and-Gold Macaw drugsAll Blue-tongue Skink drugsAll Cat (Domestic) drugsAll Chicken (Poultry) drugsAll Chinchilla drugsAll Corn Snake drugsAll Degu drugsAll Dog (Domestic) drugsAll Domestic Pigeon drugsAll Dwarf Hamster drugsAll Eastern Box Turtle drugsAll Ferret drugsAll Goldfish drugs