ExoticRx · exoticrx.com/drugs/itraconazole
Itraconazole
Sporanox, Itrafungol
Drug Class
Routes
Indications
Mechanism of Action
Inhibits fungal 14-alpha-demethylase, blocking ergosterol synthesis. Lipophilic with high tissue concentrations.
Side effects & warnings
Hepatotoxic: monitor liver enzymes. Requires acid pH for capsule absorption (give with food). Negative inotropic effect — avoid in animals with heart failure. CYP3A4 inhibitor.
Species with Itraconazole dosing data (16 dose rules)
Species references:All African Grey Parrot drugsAll Ball Python drugsAll Bearded Dragon drugsAll Cat (Domestic) drugsAll Chinchilla drugsAll Dog (Domestic) drugsAll Guinea Pig drugsAll Rabbit (Domestic) drugs
Evidence levels across 16 dose rules
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
Backed by 3 published sources
- · Carpenter's Exotic Animal Formulary, 6th Ed
- · ExoticRx 2026 (chinchilla dosing guide); Carpenter 6e
- · Plumb's Veterinary Drug Handbook, 9th Ed
Sample dosing (2 of 16 cited rules)
A dog/cat sample is shown here. Cited dosing for all 8 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
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View PlansArticles mentioning Itraconazole
- Avian Aspergillosis: Voriconazole vs Itraconazole ProtocolsWhen to reach for voriconazole instead of itraconazole in psittacine aspergillosis — and why the choice matters more in African Greys.
- Antibiotic Selection in Exotic Animals: Principles and PitfallsHow to choose an antibiotic for rabbits, guinea pigs, parrots, and reptiles — with the species-specific contraindications general practice reaches for first by reflex.
- Guinea Pig Drug Dosing: A Vet Quick ReferenceAntibiotic, analgesic, and antifungal dosing for Cavia porcellus — and why they're not just small rabbits.
- African Grey Parrot Drug Dosing: A Vet ReferenceAntibiotic, antifungal, and supportive-care dosing for Psittacus erithacus — and the avian-specific physiology that should change your prescribing.
- Bearded Dragon Respiratory Infections: Workup and TreatmentWhy a 'simple URTI' in a bearded dragon almost always has a husbandry root cause, and how to structure antibiotic therapy when it doesn't.
More Antifungal drugs
Source citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.