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Amphotericin B Liposomal

AmBisome

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Sourced from published veterinary references. Awaiting credentialed clinical reviewer — our editorial process.

Drug Class

Antifungal

Routes

IV

Indications

Invasive fungal infectionsSystemic aspergillosis

Mechanism of Action

Liposomal encapsulation targets drug to fungal cells while reducing exposure to mammalian cell membranes. Binds ergosterol causing membrane disruption.

Side effects & warnings

Least nephrotoxic amphotericin B formulation. Still monitor renal function. Infusion reactions less common. Preferred formulation in veterinary practice.

Species with Amphotericin B Liposomal dosing data (3 dose rules)

African Grey ParrotCat (Domestic)Dog (Domestic)

Species references:All African Grey Parrot drugsAll Cat (Domestic) drugsAll Dog (Domestic) drugs

Evidence levels across 3 dose rules

Strong×1Moderate×2

Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.

Backed by 2 published sources

  • · Carpenter's Exotic Animal Formulary, 6th Ed
  • · Plumb's Veterinary Drug Handbook, 9th Ed

Sample dosing (2 of 3 cited rules)

A dog/cat sample is shown here. Cited dosing for all 3 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.

SpeciesRouteDoseFrequencyEvidenceSource
Dog (Domestic)IV1–5 mg/kgq48h or 3x/weekStrongPlumb's Veterinary Drug Handbook, 9th Ed
Cat (Domestic)IV1–3 mg/kgq48h or 3x/weekModeratePlumb's Veterinary Drug Handbook, 9th Ed

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