ExoticRx · exoticrx.com/drugs/amphotericin-b
US brand names:Fungizone, Abelcet
Amphotericin B is dosed at 0.1 mg/kg intrapulmonary q 24 h for 28 d in russian tortoises, per Hernandez-Divers SJ. Pulmonary candidiasis caused by Candida albicans in a Greek tortoise (Testudo graeca) and treatment with intrapulmonary amphotericin B. J Zoo Wildl Med. 2001;32:352-359. doi:10.1638/1042-7260(2001)032[0352:pccbca]2.0.co;2 — Verified against Carpenter's Exotic Animal Formulary, 6th Ed, p.221 (2026-08-01).. Verify against current literature before clinical use.
Binds ergosterol in fungal cell membranes, creating pores that cause leakage of intracellular contents and cell death.
Severely nephrotoxic (conventional form). Lipid formulations reduce nephrotoxicity but are expensive. Pre-hydrate with IV saline. Monitor BUN/creatinine and potassium. Fever, vomiting during infusion common. Reserved for systemic mycoses.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugsAll Russian Tortoise drugs
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| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | IV | 0.5 mg/kg | q48h (every other day); practically 3x/week | Strong | Plumb's Veterinary Drug Handbook, 9th Ed — Amphotericin B, Dosages, DOGS, printed p. 76 (corpus PDF p. 103) |
| Cat (Domestic) | IV | 0.25 mg/kg | q48h (every other day); practically 3x/week | Moderate | Plumb's Veterinary Drug Handbook, 9th Ed — Amphotericin B, Dosages, CATS, printed p. 76 (corpus PDF p. 103) |
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