Sourced from published veterinary references. Awaiting credentialed clinical reviewer — our editorial process.
Amphotericin B is dosed at 1 mg/kg IV q24h in rabbits, per Plumb's Veterinary Drug Handbook, 10th ed (2023) | Sanati H, Ramos C, Bayer A, et al. Combination therapy with amphotericin B and fluconazole against invasive candidiasis in neutropenic-mouse and infective-endocarditis rabbit models. Antimicrob Agents Chemother. 1997;41:1345-1348. — Source: Carpenter's Exotic Animal Formulary, 6th Ed, p.846 — Plumb's 10th ed printed p.77, Amphotericin B monograph spanning p.74-77. — Carpenter's Exotic Animal Formulary 6th ed, Table 10.2 (Antifungal Agents Used in Rabbits.a). Verify against current literature before clinical use.
Binds ergosterol in fungal cell membranes, creating pores that cause leakage of intracellular contents and cell death.
Side effects & warnings
Severely nephrotoxic (conventional form). Lipid formulations reduce nephrotoxicity but are expensive. Pre-hydrate with IV saline. Monitor BUN/creatinine and potassium. Fever, vomiting during infusion common. Reserved for systemic mycoses.
Species with Amphotericin B dosing data (15 dose rules)
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
Sample dosing (2 of 15 cited rules)
A dog/cat sample is shown here. Cited dosing for all 14 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
Plumb's Veterinary Drug Handbook, 10th ed (2023) — Amphotericin B, Dosages, DOGS, printed p. 76Compilation only — we have not located an independent source that prints this figure.
Plumb's Veterinary Drug Handbook, 10th ed (2023) — Amphotericin B, Dosages, CATS, printed p. 76Compilation only — we have not located an independent source that prints this figure.
· 122. Meredith A. BSAVA Small Animal Formulary: Part B: Exotic Pets, British Small Animal Veterinary Association, Quedgeley, Gloucester, UK; 2015.; 130. Morrisey JK, Carpenter JW. Formulary. In: Quesenberry KE, Carpenter JW, eds. Ferrets, Rabbits, and Rodents: Clinical Medicine and Surgery, 4th ed., Elsevier, St. Louis, MO; 2021:620-630. — Source: Carpenter's Exotic Animal Formulary, 6th Ed, p.770
· 122. Meredith A. BSAVA Small Animal Formulary: Part B: Exotic Pets, British Small Animal Veterinary Association, Quedgeley, Gloucester, UK; 2015.; 130. Morrisey JK, Carpenter JW. Formulary. In: Quesenberry KE, Carpenter JW, eds. Ferrets, Rabbits, and Rodents: Clinical Medicine and Surgery, 4th ed., Elsevier, St. Louis, MO; 2021:620-630. — Source: Carpenter's Exotic Animal Formulary, 6th Ed, p.770 — Carpenter's Exotic Animal Formulary 6th ed, Table 9.1 (Antimicrobial and Antifungal Agents Used in Rodents.a).
· 63. Carpenter JW, Klaphake E, Gibbons PM, et al. Reptile formulary. In: Divers SJ, Stahl SJ, eds. Mader's Reptile and Amphibian Medicine and Surgery, 3rd ed., Elsevier, St. Louis, MO; 2019:1191-1211. — Source: Carpenter's Exotic Animal Formulary, 6th Ed, p.221 — Carpenter's Exotic Animal Formulary 6th ed, Table 4.3 (Antifungal Agents Used in Reptiles).
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· 89. Frye FL. Reptile Clinician's Handbook. Malabar, FL: Krieger Publishing; 1994. — Source: Mader's Reptile and Amphibian Medicine and Surgery, 3rd Ed, p.1404
· Besch-Williford CL. Biology and medicine of the ferret. Vet Clin North Am Small Anim Pract. 1987;17:1155-1183. — Source: Carpenter's Exotic Animal Formulary, 6th Ed, p.934 — Carpenter's Exotic Animal Formulary 6th ed, Table 11.2 (Antifungal Agents Used in Ferrets).
· Carpenter JW, Klaphake E, Gibbons PM, et al. Reptile formulary. In: Divers SJ, Stahl SJ, eds. Mader's Reptile and Amphibian Medicine and Surgery, 3rd ed., Elsevier, St. Louis, MO; 2019:1191-1211. — Source: Carpenter's Exotic Animal Formulary, 6th Ed, p.221 — Carpenter's Exotic Animal Formulary 6th ed, Table 4.3 (Antifungal Agents Used in Reptiles).
· Hernandez-Divers SJ. Pulmonary candidiasis caused by Candida albicans in a Greek tortoise (Testudo graeca) and treatment with intrapulmonary amphotericin B. J Zoo Wildl Med. 2001;32:352-359. doi:10.1638/1042-7260(2001)032[0352:pccbca]2.0.co;2 — Carpenter's Exotic Animal Formulary 6th ed, Table 4.3 (Antifungal Agents Used in Reptiles).
· Meredith A. BSAVA Small Animal Formulary: Part B: Exotic Pets, British Small Animal Veterinary Association, Quedgeley, Gloucester, UK; 2015. — Source: Carpenter's Exotic Animal Formulary, 6th Ed, p.770 — Carpenter's Exotic Animal Formulary 6th ed, Table 9.1 (Antimicrobial and Antifungal Agents Used in Rodents.a).
· Plumb's Veterinary Drug Handbook, 10th ed (2023) | Sanati H, Ramos C, Bayer A, et al. Combination therapy with amphotericin B and fluconazole against invasive candidiasis in neutropenic-mouse and infective-endocarditis rabbit models. Antimicrob Agents Chemother. 1997;41:1345-1348. — Source: Carpenter's Exotic Animal Formulary, 6th Ed, p.846 — Plumb's 10th ed printed p.77, Amphotericin B monograph spanning p.74-77. — Carpenter's Exotic Animal Formulary 6th ed, Table 10.2 (Antifungal Agents Used in Rabbits.a).
· Plumb's Veterinary Drug Handbook, 10th ed (2023) — Amphotericin B, Dosages, CATS, printed p. 76
· Plumb's Veterinary Drug Handbook, 10th ed (2023) — Amphotericin B, Dosages, DOGS, printed p. 76
Amphotericin B (Fungizone, Abelcet) Dosage | ExoticRx