Reptile · Testudo horsfieldii · typical adult weight 0.23–0.91 kg
Amphotericin B is dosed at 0.1 mg/kg intrapulmonary q 24 h for 28 d in russian tortoises, per Hernandez-Divers SJ. Pulmonary candidiasis caused by Candida albicans in a Greek tortoise (Testudo graeca) and treatment with intrapulmonary amphotericin B. J Zoo Wildl Med. 2001;32:352-359. doi:10.1638/1042-7260(2001)032[0352:pccbca]2.0.co;2 — Verified against Carpenter's Exotic Animal Formulary, 6th Ed, p.221 (2026-08-01). — Carpenter's Exotic Animal Formulary 6th ed, Table 4.3 (Antifungal Agents Used in Reptiles). The copy held is an ebook conversion with no printed page numbers, so the table — not the page — is the citable location. — SOURCE EDITION: Carpenter's Exotic Animal Formulary — ISBN 9780323833929, https://openlibrary.org/isbn/9780323833929. Amphotericin B is used in russian tortoises for Pulmonary mycosis (candidiasis) / fungal pneumonia. Routes documented in russian tortoises: intrapulmonary. A typical adult russian tortoise weighs 0.23–0.91 kg. ExoticRx lists 1 cited dose rule for Amphotericin B in russian tortoises, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Fungizone, Abelcet
| Route | Dose | Frequency | Indication | Evidence | Source |
|---|---|---|---|---|---|
| intrapulmonary | 0.1 mg/kg | q 24 h for 28 d | Pulmonary mycosis (candidiasis) / fungal pneumonia | Weak | Hernandez-Divers SJ. Pulmonary candidiasis caused by Candida albicans in a Greek tortoise (Testudo graeca) and treatment with intrapulmonary amphotericin B. J Zoo Wildl Med. 2001;32:352-359. doi:10.1638/1042-7260(2001)032[0352:pccbca]2.0.co;2 — Verified against Carpenter's Exotic Animal Formulary, 6th Ed, p.221 (2026-08-01). — Carpenter's Exotic Animal Formulary 6th ed, Table 4.3 (Antifungal Agents Used in Reptiles). The copy held is an ebook conversion with no printed page numbers, so the table — not the page — is the citable location. — SOURCE EDITION: Carpenter's Exotic Animal Formulary — ISBN 9780323833929, https://openlibrary.org/isbn/9780323833929 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
The sources disagree for this combination. The ranges below do not overlap on a comparable route. This is not an error in one of them — published veterinary references differ, and reconciling them for a particular patient is a clinical judgement.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 0.5–1 | IV | BSAVA Small Animal Formulary, 10th ed — Part B (Exotic Pets)p.35 | 0.5-1 mg/kg i.v., intracoelomic q24-72h for 2-4 weeks, concurrent fluid therapy is advised due to po |
| 0.5 | IV | Mader's Reptile and Amphibian Medicine and Surgery, 3rd edTable 127.1 | 0.5 mg/kg IV q48-72h89 0.5-1 mg/kg IV, ICe q24-72h × 1 mg/kg IT q24h × 14-28 days14 0.1 mg/kg intrapulmonary q24h Most species/nephrotoxic; can use in combination with ketoconazole |
| 0.5–1 | IV | Mader's Reptile and Amphibian Medicine and Surgery, 3rd edTable 127.1 | 0.5 mg/kg IV q48-72h89 0.5-1 mg/kg IV, ICe q24-72h × 1 mg/kg IT q24h × 14-28 days14 0.1 mg/kg intrapulmonary q24h Most species/nephrotoxic; can use in combination with ketoconazole |
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Binds ergosterol in fungal cell membranes, creating pores that cause leakage of intracellular contents and cell death.
Severely nephrotoxic (conventional form). Lipid formulations reduce nephrotoxicity but are expensive. Pre-hydrate with IV saline. Monitor BUN/creatinine and potassium. Fever, vomiting during infusion common. Reserved for systemic mycoses.
Species-specific contraindications and adverse-reaction reports for russian tortoises may differ from canine / feline reference data — consult the primary citations listed with each rule.
Amphotericin B dose range in russian tortoises, with cited source references: intrapulmonary 0.1 mg/kg q 24 h for 28 d. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Amphotericin B in russian tortoises: intrapulmonary.
Amphotericin B is indicated in russian tortoises for: Pulmonary mycosis (candidiasis) / fungal pneumonia.
These are general warnings for Amphotericin B across species; consult the russian tortoise dosing table above for species-specific guidance. Severely nephrotoxic (conventional form). Lipid formulations reduce nephrotoxicity but are expensive. Pre-hydrate with IV saline. Monitor BUN/creatinine and potassium. Fever, vomiting during infusion common. Reserved for systemic mycoses.
Why a species-specific page? Amphotericin B pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in russian tortoises — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.
| 1 | IV | Mader's Reptile and Amphibian Medicine and Surgery, 3rd edTable 127.1 | 0.5 mg/kg IV q48-72h89 0.5-1 mg/kg IV, ICe q24-72h × 1 mg/kg IT q24h × 14-28 days14 0.1 mg/kg intrapulmonary q24h Most species/nephrotoxic; can use in combination with ketoconazole |
| 0.1 | IV | Mader's Reptile and Amphibian Medicine and Surgery, 3rd edTable 127.1 | 0.5 mg/kg IV q48-72h89 0.5-1 mg/kg IV, ICe q24-72h × 1 mg/kg IT q24h × 14-28 days14 0.1 mg/kg intrapulmonary q24h Most species/nephrotoxic; can use in combination with ketoconazole |
| 1 | ICE | Mader's Reptile and Amphibian Medicine and Surgery, 3rd edTable 127.1 | 1 mg/kg q24h ICe × 2-4 wk185 5 mg/150 mL saline × 1 hr nebu × 7 days143 Crocodilians lization q12h Most species/pneumonia |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.