Reptile · Terrapene carolina · typical adult weight 0.30–0.60 kg
Amphotericin B is dosed at 0.5 mg/kg IV q48-72h in eastern box turtles, per 89. Frye FL. Reptile Clinician's Handbook. Malabar, FL: Krieger Publishing; 1994. — Source: Mader's Reptile and Amphibian Medicine and Surgery, 3rd Ed, p.1404 — SOURCE EDITION: Mader's Reptile and Amphibian Medicine and Surgery (Divers & Stahl) — ISBN 9780323482530, https://openlibrary.org/isbn/9780323482530. Amphotericin B is used in eastern box turtles for systemic mycosis. Routes documented in eastern box turtles: IV. A typical adult eastern box turtle weighs 0.30–0.60 kg. ExoticRx lists 1 cited dose rule for Amphotericin B in eastern box turtles, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Fungizone, Abelcet
| Route | Dose | Frequency | Indication | Evidence | Source |
|---|---|---|---|---|---|
| IV | 0.5 mg/kg | q48-72h | systemic mycosis | Weak | 89. Frye FL. Reptile Clinician's Handbook. Malabar, FL: Krieger Publishing; 1994. — Source: Mader's Reptile and Amphibian Medicine and Surgery, 3rd Ed, p.1404 — SOURCE EDITION: Mader's Reptile and Amphibian Medicine and Surgery (Divers & Stahl) — ISBN 9780323482530, https://openlibrary.org/isbn/9780323482530 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
The sources disagree for this combination. The ranges below do not overlap on a comparable route. This is not an error in one of them — published veterinary references differ, and reconciling them for a particular patient is a clinical judgement.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 0.5–1 | IV | BSAVA Small Animal Formulary, 10th ed — Part B (Exotic Pets)p.35 | 0.5-1 mg/kg i.v., intracoelomic q24-72h for 2-4 weeks, concurrent fluid therapy is advised due to po |
| 0.5 | IV | Mader's Reptile and Amphibian Medicine and Surgery, 3rd edTable 127.1 | 0.5 mg/kg IV q48-72h89 0.5-1 mg/kg IV, ICe q24-72h × 1 mg/kg IT q24h × 14-28 days14 0.1 mg/kg intrapulmonary q24h Most species/nephrotoxic; can use in combination with ketoconazole |
| 0.5–1 | IV | Mader's Reptile and Amphibian Medicine and Surgery, 3rd edTable 127.1 | 0.5 mg/kg IV q48-72h89 0.5-1 mg/kg IV, ICe q24-72h × 1 mg/kg IT q24h × 14-28 days14 0.1 mg/kg intrapulmonary q24h Most species/nephrotoxic; can use in combination with ketoconazole |
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These ranges are per kg. Enter your eastern box turtle's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Binds ergosterol in fungal cell membranes, creating pores that cause leakage of intracellular contents and cell death.
Severely nephrotoxic (conventional form). Lipid formulations reduce nephrotoxicity but are expensive. Pre-hydrate with IV saline. Monitor BUN/creatinine and potassium. Fever, vomiting during infusion common. Reserved for systemic mycoses.
Species-specific contraindications and adverse-reaction reports for eastern box turtles may differ from canine / feline reference data — consult the primary citations listed with each rule.
Amphotericin B dose range in eastern box turtles, with cited source references: IV 0.5 mg/kg q48-72h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Amphotericin B in eastern box turtles: IV.
Amphotericin B is indicated in eastern box turtles for: systemic mycosis.
These are general warnings for Amphotericin B across species; consult the eastern box turtle dosing table above for species-specific guidance. Severely nephrotoxic (conventional form). Lipid formulations reduce nephrotoxicity but are expensive. Pre-hydrate with IV saline. Monitor BUN/creatinine and potassium. Fever, vomiting during infusion common. Reserved for systemic mycoses.
Why a species-specific page? Amphotericin B pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in eastern box turtles — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.
| 1 | IV | Mader's Reptile and Amphibian Medicine and Surgery, 3rd edTable 127.1 | 0.5 mg/kg IV q48-72h89 0.5-1 mg/kg IV, ICe q24-72h × 1 mg/kg IT q24h × 14-28 days14 0.1 mg/kg intrapulmonary q24h Most species/nephrotoxic; can use in combination with ketoconazole |
| 0.1 | IV | Mader's Reptile and Amphibian Medicine and Surgery, 3rd edTable 127.1 | 0.5 mg/kg IV q48-72h89 0.5-1 mg/kg IV, ICe q24-72h × 1 mg/kg IT q24h × 14-28 days14 0.1 mg/kg intrapulmonary q24h Most species/nephrotoxic; can use in combination with ketoconazole |
| 1 | ICE | Mader's Reptile and Amphibian Medicine and Surgery, 3rd edTable 127.1 | 1 mg/kg q24h ICe × 2-4 wk185 5 mg/150 mL saline × 1 hr nebu × 7 days143 Crocodilians lization q12h Most species/pneumonia |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.