Reptile · Terrapene carolina · typical adult weight 0.30–0.60 kg
Itraconazole is dosed at 5 mg/kg PO q24h in eastern box turtles, per 214. Martel A, Hellebuyck T, Van Waeyenberghe L. Treatment of infections with Nannizziopsis vriesii, an emergent reptilian dermatophytea. Proc Annu Conf Assoc Rept Amph Vet. 2009;69-70. — Source: Mader's Reptile and Amphibian Medicine and Surgery, 3rd Ed, p.1405 — SOURCE EDITION: Mader's Reptile and Amphibian Medicine and Surgery (Divers & Stahl) — ISBN 9780323482530, https://openlibrary.org/isbn/9780323482530. Itraconazole is used in eastern box turtles for systemic/cutaneous mycosis. Routes documented in eastern box turtles: PO. A typical adult eastern box turtle weighs 0.30–0.60 kg. ExoticRx lists 1 cited dose rule for Itraconazole in eastern box turtles, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Sporanox, Itrafungol
| Route | Dose | Frequency | Indication | Evidence | Source |
|---|---|---|---|---|---|
| PO | 5 mg/kg | q24h | systemic/cutaneous mycosis | Weak | 214. Martel A, Hellebuyck T, Van Waeyenberghe L. Treatment of infections with Nannizziopsis vriesii, an emergent reptilian dermatophytea. Proc Annu Conf Assoc Rept Amph Vet. 2009;69-70. — Source: Mader's Reptile and Amphibian Medicine and Surgery, 3rd Ed, p.1405 — SOURCE EDITION: Mader's Reptile and Amphibian Medicine and Surgery (Divers & Stahl) — ISBN 9780323482530, https://openlibrary.org/isbn/9780323482530 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
The sources disagree for this combination. The ranges below do not overlap on a comparable route. This is not an error in one of them — published veterinary references differ, and reconciling them for a particular patient is a clinical judgement.
| Dose (%) | Route | Source | As printed |
|---|---|---|---|
| 1 | TOPICAL | Mader's Reptile and Amphibian Medicine and Surgery, 3rd edTable 128.1 | mg/kg PO q24h52 01% in 0.6% salt solution x 5 min bath q24h × 1 01% in buffered solution x 5 min bath q24h × 11 days16 Topical route best choice to treat chytridiomycosis; caution |
| 0.6 | TOPICAL | Mader's Reptile and Amphibian Medicine and Surgery, 3rd edTable 128.1 | mg/kg PO q24h52 01% in 0.6% salt solution x 5 min bath q24h × 1 01% in buffered solution x 5 min bath q24h × 11 days16 Topical route best choice to treat chytridiomycosis; caution |
| Dose (mg/kg) | Route | Source |
|---|
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These ranges are per kg. Enter your eastern box turtle's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Inhibits fungal 14-alpha-demethylase, blocking ergosterol synthesis. Lipophilic with high tissue concentrations.
Hepatotoxic: monitor liver enzymes. Requires acid pH for capsule absorption (give with food). Negative inotropic effect — avoid in animals with heart failure. CYP3A4 inhibitor.
Species-specific contraindications and adverse-reaction reports for eastern box turtles may differ from canine / feline reference data — consult the primary citations listed with each rule.
Itraconazole dose range in eastern box turtles, with cited source references: PO 5 mg/kg q24h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Itraconazole in eastern box turtles: PO.
Itraconazole is indicated in eastern box turtles for: systemic/cutaneous mycosis.
These are general warnings for Itraconazole across species; consult the eastern box turtle dosing table above for species-specific guidance. Hepatotoxic: monitor liver enzymes. Requires acid pH for capsule absorption (give with food). Negative inotropic effect — avoid in animals with heart failure. CYP3A4 inhibitor.
Why a species-specific page? Itraconazole pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in eastern box turtles — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.
| As printed |
|---|
| 5–10 | PO | BSAVA Small Animal Formulary, 10th ed — Part B (Exotic Pets)p.183 | 5-10 mg/kg p.o. q24h (most species). Metabolically scaled doses have been suggested for the treatme |
| 15 | PO | Carpenter's Exotic Animal Formulary, 6th edTable 4.3 | 5 mg/kg PO q24h, or 15 mg/kg PO q72h |
| 5 | PO | Carpenter's Exotic Animal Formulary, 6th edTable 4.3 | 5 mg/kg PO q24h, or 15 mg/kg PO q72h |
| 5 | — | Mader's Reptile and Amphibian Medicine and Surgery, 3rd edTable 127.3 | 5 mg/kg SC184 Cottonmouths/deaths in 3 out of 4 animals; not recommended |
| 5 | PO | Mader's Reptile and Amphibian Medicine and Surgery, 3rd edTable 127.3 | 5 mg/kg PO q24h214 Most species/some hepatotoxicity noted when used for Chrysosporium anamorph of Nannizziopsis vriesii; can cause anorexia in bearded dragons without evidence of h |
| 15 | PO | Mader's Reptile and Amphibian Medicine and Surgery, 3rd edTable 127.3 | 5 mg/kg PO q24h, or 15 mg/kg PO q72h204 Kemp’s ridley sea turtles |
| Dose (mg/l) | Route | Source | As printed |
|---|---|---|---|
| 15 | — | Mader's Reptile and Amphibian Medicine and Surgery, 3rd edTable 128.1 | 5-1.5 mg/L × 5 min bath q24h × 7 days15 mg/L x 5 min bath q24h × 10 days22 Alytes muletensis tadpoles/safe at varying concentrations and duration of 7-28 days; confirmed negative P |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.