Reptile · Terrapene carolina · typical adult weight 0.30–0.60 kg
Ketoconazole is dosed at 15 mg/kg PO q72h in eastern box turtles, per 149. Jepson L. Lizards. Exotic Animal Medicine: A Quick Reference Guide. Philadelphia: Saunders/Elsevier; 2009:268-314. | 150. Jepson L. Snakes. Exotic Animal Medicine: A Quick Reference Guide. Philadelphia: Saunders/Elsevier; 2009:315-357. | 151. Jepson L. Turtles and tortoises. Exotic Animal Medicine: A Quick Reference Guide. Philadelphia: Saunders/Elsevier; 2009:358-411. — Source: Mader's Reptile and Amphibian Medicine and Surgery, 3rd Ed, p.1405 — SOURCE EDITION: Mader's Reptile and Amphibian Medicine and Surgery (Divers & Stahl) — ISBN 9780323482530, https://openlibrary.org/isbn/9780323482530. Ketoconazole is used in eastern box turtles for mycosis. Routes documented in eastern box turtles: PO. A typical adult eastern box turtle weighs 0.30–0.60 kg. ExoticRx lists 1 cited dose rule for Ketoconazole in eastern box turtles, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Nizoral
| Route | Dose | Frequency | Indication | Evidence | Source |
|---|---|---|---|---|---|
| PO | 15 mg/kg | q72h | mycosis | Weak | 149. Jepson L. Lizards. Exotic Animal Medicine: A Quick Reference Guide. Philadelphia: Saunders/Elsevier; 2009:268-314. | 150. Jepson L. Snakes. Exotic Animal Medicine: A Quick Reference Guide. Philadelphia: Saunders/Elsevier; 2009:315-357. | 151. Jepson L. Turtles and tortoises. Exotic Animal Medicine: A Quick Reference Guide. Philadelphia: Saunders/Elsevier; 2009:358-411. — Source: Mader's Reptile and Amphibian Medicine and Surgery, 3rd Ed, p.1405 — SOURCE EDITION: Mader's Reptile and Amphibian Medicine and Surgery (Divers & Stahl) — ISBN 9780323482530, https://openlibrary.org/isbn/9780323482530 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
The sources disagree for this combination. The ranges below do not overlap on a comparable route. This is not an error in one of them — published veterinary references differ, and reconciling them for a particular patient is a clinical judgement.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 15 | PO | Carpenter's Exotic Animal Formulary, 6th edTable 4.3 | 15 mg/kg q72h PO,222,243 |
| 25 | PO | Carpenter's Exotic Animal Formulary, 6th edTable 4.3 | 25 mg/kg PO q24h × 21 days |
| 15 | — | Mader's Reptile and Amphibian Medicine and Surgery, 3rd edTable 127.3 | 15 mg/kg q72h PO149-151 Most species |
| 25 | PO |
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These ranges are per kg. Enter your eastern box turtle's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Inhibits lanosterol 14-alpha-demethylase (CYP51), blocking ergosterol synthesis in fungal membranes. At high doses, inhibits adrenal and gonadal steroidogenesis.
Hepatotoxic — monitor liver enzymes. Strong CYP inhibitor (many drug interactions). Requires gastric acid for absorption (do not give with antacids). Also used for Cushing's disease (adrenal steroidogenesis inhibition).
Species-specific contraindications and adverse-reaction reports for eastern box turtles may differ from canine / feline reference data — consult the primary citations listed with each rule.
Ketoconazole dose range in eastern box turtles, with cited source references: PO 15 mg/kg q72h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Ketoconazole in eastern box turtles: PO.
Ketoconazole is indicated in eastern box turtles for: mycosis.
These are general warnings for Ketoconazole across species; consult the eastern box turtle dosing table above for species-specific guidance. Hepatotoxic — monitor liver enzymes. Strong CYP inhibitor (many drug interactions). Requires gastric acid for absorption (do not give with antacids). Also used for Cushing's disease (adrenal steroidogenesis inhibition).
Why a species-specific page? Ketoconazole pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in eastern box turtles — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.
| 25 mg/kg PO q24h × 21 days144 Snakes, turtles |
| 15–30 | PO | Mader's Reptile and Amphibian Medicine and Surgery, 3rd edTable 127.3 | 15-30 mg/kg PO q24h × 14-28 days217,260 Chelonians/PK (gopher tortoises); systemic infection |
| 50 | PO | Mader's Reptile and Amphibian Medicine and Surgery, 3rd edTable 127.3 | 50 mg/kg PO q24h × 14-28 days99 Crocodilians |
| 10–20 | PO | Mader's Reptile and Amphibian Medicine and Surgery, 3rd edTable 128.2 | 10-20 mg/kg PO q24h52 Topical cream52 |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.