Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Amphotericin B is dosed at 0.5 mg/kg IV q48h (every other day); practically 3x/week in dogs, per Plumb's Veterinary Drug Handbook, 9th Ed — Amphotericin B, Dosages, DOGS, printed p. 76 (corpus PDF p. 103). Amphotericin B is used in dogs for Systemic mycoses (blastomycosis, histoplasmosis, coccidioidomycosis). Routes documented in dogs: IV. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Amphotericin B in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Fungizone, Abelcet
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 0.5 mg/kg | q48h (every other day); practically 3x/week | Cumulative dose 8-12 mg/kg total | Systemic mycoses (blastomycosis, histoplasmosis, coccidioidomycosis) | Strong | Plumb's Veterinary Drug Handbook, 9th Ed — Amphotericin B, Dosages, DOGS, printed p. 76 (corpus PDF p. 103) |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Binds ergosterol in fungal cell membranes, creating pores that cause leakage of intracellular contents and cell death.
Severely nephrotoxic (conventional form). Lipid formulations reduce nephrotoxicity but are expensive. Pre-hydrate with IV saline. Monitor BUN/creatinine and potassium. Fever, vomiting during infusion common. Reserved for systemic mycoses.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Amphotericin B dose range in dogs, with cited source references: IV 0.5 mg/kg q48h (every other day); practically 3x/week. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Amphotericin B in dogs: IV.
Cited course lengths for Amphotericin B in dogs include: Cumulative dose 8-12 mg/kg total. Duration depends on the indication — match it to the specific dose rule in the table above.
Amphotericin B is indicated in dogs for: Systemic mycoses (blastomycosis, histoplasmosis, coccidioidomycosis).
These are general warnings for Amphotericin B across species; consult the dog dosing table above for species-specific guidance. Severely nephrotoxic (conventional form). Lipid formulations reduce nephrotoxicity but are expensive. Pre-hydrate with IV saline. Monitor BUN/creatinine and potassium. Fever, vomiting during infusion common. Reserved for systemic mycoses.
Why a species-specific page? Amphotericin B pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.