Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Amphotericin B is dosed at 0.5 mg/kg IV q48h (every other day); practically 3x/week in dogs, per Plumb's Veterinary Drug Handbook, 10th ed (2023, held copy; the original seed cited the 9th, which was never consulted) — Amphotericin B, Dosages, DOGS, printed p. 76 (corpus PDF p. 103) — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Amphotericin B is used in dogs for Systemic mycoses (blastomycosis, histoplasmosis, coccidioidomycosis). Routes documented in dogs: IV. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Amphotericin B in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Fungizone, Abelcet
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 0.5 mg/kg | q48h (every other day); practically 3x/week | Cumulative dose 8-12 mg/kg total | Systemic mycoses (blastomycosis, histoplasmosis, coccidioidomycosis) | Weak | Plumb's Veterinary Drug Handbook, 10th ed (2023, held copy; the original seed cited the 9th, which was never consulted) — Amphotericin B, Dosages, DOGS, printed p. 76 (corpus PDF p. 103) — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 0.25–1 | IV | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.42 | % dextrose water to give 0.1 mg/ml solution. Alternatively, 0.25-1 mg/kg may be dissolved in 10-60 ml 5% dextrose given over 10 min i.v. 3 times a week. |
| 4–8 | — | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.42 | of therapy are often necessary. A total cumulative dose of 4-8 mg/kg is recommended by some authors. • Cryptococcosis (conventional amphotericin, s |
| 0.5–0.8 | — | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.42 | ventional amphotericin, subcutaneous alternative): 0.5-0.8 mg/kg added to 400-500 ml of 0.45% saline/2.5% dextrose. This total volume is then administered |
| 8–26 | — |
Need the exact dose for your patient?
These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Binds ergosterol in fungal cell membranes, creating pores that cause leakage of intracellular contents and cell death.
Severely nephrotoxic (conventional form). Lipid formulations reduce nephrotoxicity but are expensive. Pre-hydrate with IV saline. Monitor BUN/creatinine and potassium. Fever, vomiting during infusion common. Reserved for systemic mycoses.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Amphotericin B dose range in dogs, with cited source references: IV 0.5 mg/kg q48h (every other day); practically 3x/week. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Amphotericin B in dogs: IV.
Cited course lengths for Amphotericin B in dogs include: Cumulative dose 8-12 mg/kg total. Duration depends on the indication — match it to the specific dose rule in the table above.
Amphotericin B is indicated in dogs for: Systemic mycoses (blastomycosis, histoplasmosis, coccidioidomycosis).
These are general warnings for Amphotericin B across species; consult the dog dosing table above for species-specific guidance. Severely nephrotoxic (conventional form). Lipid formulations reduce nephrotoxicity but are expensive. Pre-hydrate with IV saline. Monitor BUN/creatinine and potassium. Fever, vomiting during infusion common. Reserved for systemic mycoses.
Why a species-specific page? Amphotericin B pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.
| BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.42 |
| red s.c. 2-3-times a week to a cumulative level of 8-26 mg/kg. Do not inject solutions more concentrated than 20 mg/l as they will B |
| 1 | PO | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.43 | s may also be performed in this condition at a dose of 1 mg/kg q7d in combination with oral itraconazole. |
| 1 | IV | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.42 | Lipid formulations (general guidelines): 1 mg/kg q48h to cumulative dose of 12 mg/kg. Higher doses are tolerated (e.g. 1-2.5 mg/kg i |
| 12 | IV | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.42 | eneral guidelines): 1 mg/kg q48h to cumulative dose of 12 mg/kg. Higher doses are tolerated (e.g. 1-2.5 mg/kg i.v. q48h for 4 weeks/to cumulative |
| 1–2.5 | IV | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.42 | ve dose of 12 mg/kg. Higher doses are tolerated (e.g. 1-2.5 mg/kg i.v. q48h for 4 weeks/to cumulative dose of 24-30 mg/kg). Reconstitute to 5 mg/ml wi |
| 24–30 | — | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.42 | -2.5 mg/kg i.v. q48h for 4 weeks/to cumulative dose of 24-30 mg/kg). Reconstitute to 5 mg/ml with sterile water, then dilute required volume to 1 mg/m |
| 10 | PO | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.42 | se rate gradually. A total cumulative dose of at least 10 mg/kg is required but treatment may be continued long term depending on clinical response. |
| Dose (mg/l) | Route | Source | As printed |
|---|---|---|---|
| 20 | IM | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.42 | g. Do not inject solutions more concentrated than 20 mg/l as they will BSAVA Small Animal Formulary 10th edition: Part A - Canine and Feli |
| Dose (mg/ml) | Route | Source | As printed |
|---|---|---|---|
| 5 | IV | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.42 | y over 4-6 hours. Reconstitute vial with 10 ml water giving 5 mg/ml solution; dilute required volume further 1:50 with 5% dextrose water to give 0.1 |
| 0.1 | IV | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.42 | volume further 1:50 with 5% dextrose water to give 0.1 mg/ml solution. Alternatively, 0.25-1 mg/kg may be dissolved in 10-60 ml 5% dextrose g |
| 5 | — | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.42 | ks/to cumulative dose of 24-30 mg/kg). Reconstitute to 5 mg/ml with sterile water, then dilute required volume to 1 mg/ml with 5% dextrose wa |
| 1 | IV | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.42 | ml with sterile water, then dilute required volume to 1 mg/ml with 5% dextrose water. • Leishmaniosis (lipid formulations): 1-2.5 mg/kg i.v. t |
| Dose (ml/kg) | Route | Source | As printed |
|---|---|---|---|
| 5–10 | — | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.42 | mg in 50-100 ml of sterile water infused at a rate of 5-10 ml/kg into the bladder lumen daily for 5-15 days. |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.