Amphotericin B for Dog
Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Amphotericin B is used in dog for Systemic mycoses (blastomycosis, histoplasmosis, coccidioidomycosis). Routes documented in dog: IV. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Amphotericin B in dog, drawn from published veterinary references. Verify against current literature before clinical use.
Trade names: Fungizone, Abelcet
Dose ranges
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 0.5–1 mg/kg | q48h or 3x/week | Cumulative dose 8-12 mg/kg total | Systemic mycoses (blastomycosis, histoplasmosis, coccidioidomycosis) | Strong | Plumb's Veterinary Drug Handbook, 9th Ed |
Need the exact dose for your patient?
These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Mechanism of action
Binds ergosterol in fungal cell membranes, creating pores that cause leakage of intracellular contents and cell death.
Side effects & warnings
Severely nephrotoxic (conventional form). Lipid formulations reduce nephrotoxicity but are expensive. Pre-hydrate with IV saline. Monitor BUN/creatinine and potassium. Fever, vomiting during infusion common. Reserved for systemic mycoses.
Species-specific contraindications and adverse-reaction reports for dog may differ from canine / feline reference data — consult the primary citations listed with each rule.
Other Antifungal drugs with dog dosing
Amphotericin B dosing in other species
Why a species-specific page? Amphotericin B pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dog — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.