Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Fluconazole is dosed at 5–10 mg/kg IV q12-24h in dogs, per Mazepa AS, Trepanier LA, Foy DS. Retrospective comparison of the efficacy of fluconazole or itraconazole for the treatment of systemic blastomycosis in dogs. J Vet Intern Med. 2011;25(3):440-445. doi:10.1111/j.1939-1676.2011.0710.x; Wilson AG, KuKanich KS, Hanzlicek AS, Payton ME. Clinical signs, treatment, and prognostic factors for dogs with histoplasmosis. J Am Vet Med Assoc. 2018;252:201-209. doi:10.2460/javma.252.2.201 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.559 (2026-08-01). — Plumb's 10th ed (held) printed p.532, Fluconazole monograph spanning p.530-533; page located 2026-08-05 from the book's own running heads, and carries this exact dose under the matching species heading. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Fluconazole is used in dogs for Severe CNS fungal infections, Systemic mycoses caused by fluconazole-sensitive organisms (cryptococcosis, blastomycosis, histoplasmosis), Systemic fungal infections, CNS fungal infections, Blastomycosis (CNS involvement adjunct). Routes documented in dogs: IV, PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 4 cited dose rules for Fluconazole in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Diflucan
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 5–10 mg/kg | q12-24h | Until oral feasible | Severe CNS fungal infections | Moderate | Mazepa AS, Trepanier LA, Foy DS. Retrospective comparison of the efficacy of fluconazole or itraconazole for the treatment of systemic blastomycosis in dogs. J Vet Intern Med. 2011;25(3):440-445. doi:10.1111/j.1939-1676.2011.0710.x; Wilson AG, KuKanich KS, Hanzlicek AS, Payton ME. Clinical signs, treatment, and prognostic factors for dogs with histoplasmosis. J Am Vet Med Assoc. 2018;252:201-209. doi:10.2460/javma.252.2.201 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.559 (2026-08-01). — Plumb's 10th ed (held) printed p.532, Fluconazole monograph spanning p.530-533; page located 2026-08-05 from the book's own running heads, and carries this exact dose under the matching species heading. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
| PO | 5–10 mg/kg | q12h | 12+ months; lifelong in some cases | Systemic mycoses caused by fluconazole-sensitive organisms (cryptococcosis, blastomycosis, histoplasmosis) | Strong | Mazepa AS, Trepanier LA, Foy DS. Retrospective comparison of the efficacy of fluconazole or itraconazole for the treatment of systemic blastomycosis in dogs. J Vet Intern Med. 2011;25(3):440-445. ; Wilson AG, KuKanich KS, Hanzlicek AS, Payton ME. Clinical signs, treatment, and prognostic factors for dogs with histoplasmosis. J Am Vet Med Assoc. 2018;252:201-209. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.559 (2026-08-01). — Plumb's 10th ed (held) printed p.532, Fluconazole monograph spanning p.530-533; page located 2026-08-05 from the book's own running heads, and carries this exact dose under the matching species heading. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, — Plumb's Veterinary Drug Handbook, 10th ed (held), Fluconazole monograph, printed p.532 (corpus PDF p.559), DOGS: "Systemic mycosis for fluconazole-sensitive organisms (potentially cryptococcosis, blastomycosis […]" [INDICATION AND NOTES CORRECTED 2026-08-12, two readers — coccidioidomycosis is named on that page only under the CATS heading, and the canine coccidioidal entry is 18 mg/kg/day PO.] |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
The sources disagree for this combination. The ranges below do not overlap on a comparable route. This is not an error in one of them — published veterinary references differ, and reconciling them for a particular patient is a clinical judgement.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 2.5–5 | PO | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.183 | 2.5-5 mg/kg p.o. q12h |
| 5–10 | — | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.183 | 5-10 mg/kg q24h. |
| 5 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.358 | • 5 mg/kg q12h PO. In refractory cases, increase dose to 10 mg/kg q12h PO. |
| 10 | PO |
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Inhibits fungal cytochrome P450 enzyme 14-alpha-demethylase, blocking ergosterol synthesis and disrupting fungal cell membrane.
Hepatotoxic: monitor liver enzymes during prolonged therapy. Drug interactions via CYP450 inhibition. Good CNS and ocular penetration.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Fluconazole dose ranges in dogs, with cited source references: IV 5–10 mg/kg q12-24h; PO 5–10 mg/kg q12h; PO 5–10 mg/kg q12-24h; PO 5–10 mg/kg q12h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Fluconazole in dogs: IV, PO.
Cited course lengths for Fluconazole in dogs include: Until oral feasible; 12+ months; lifelong in some cases; Weeks to months depending on infection; Months (combined with itraconazole). Duration depends on the indication — match it to the specific dose rule in the table above.
Fluconazole is indicated in dogs for: Severe CNS fungal infections, Systemic mycoses caused by fluconazole-sensitive organisms (cryptococcosis, blastomycosis, histoplasmosis), Systemic fungal infections, CNS fungal infections, Blastomycosis (CNS involvement adjunct).
These are general warnings for Fluconazole across species; consult the dog dosing table above for species-specific guidance. Hepatotoxic: monitor liver enzymes during prolonged therapy. Drug interactions via CYP450 inhibition. Good CNS and ocular penetration.
Why a species-specific page? Fluconazole pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.
| PO | 5–10 mg/kg | q12-24h | Weeks to months depending on infection | Systemic fungal infections, CNS fungal infections | Strong | Mazepa AS, Trepanier LA, Foy DS. Retrospective comparison of the efficacy of fluconazole or itraconazole for the treatment of systemic blastomycosis in dogs. J Vet Intern Med. 2011;25(3):440-445. doi:10.1111/j.1939-1676.2011.0710.x; Wilson AG, KuKanich KS, Hanzlicek AS, Payton ME. Clinical signs, treatment, and prognostic factors for dogs with histoplasmosis. J Am Vet Med Assoc. 2018;252:201-209. doi:10.2460/javma.252.2.201 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.559 (2026-08-01). — Plumb's 10th ed (held) printed p.532, Fluconazole monograph spanning p.530-533; page located 2026-08-05 from the book's own running heads, and carries this exact dose under the matching species heading. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
| PO | 5–10 mg/kg | q12h | Months (combined with itraconazole) | Blastomycosis (CNS involvement adjunct) | Moderate | Mazepa AS, Trepanier LA, Foy DS. Retrospective comparison of the efficacy of fluconazole or itraconazole for the treatment of systemic blastomycosis in dogs. J Vet Intern Med. 2011;25(3):440-445. doi:10.1111/j.1939-1676.2011.0710.x; Wilson AG, KuKanich KS, Hanzlicek AS, Payton ME. Clinical signs, treatment, and prognostic factors for dogs with histoplasmosis. J Am Vet Med Assoc. 2018;252:201-209. doi:10.2460/javma.252.2.201 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.559 (2026-08-01). — Plumb's 10th ed (held) printed p.532, Fluconazole monograph spanning p.530-533; page located 2026-08-05 from the book's own running heads, and carries this exact dose under the matching species heading. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
| Papich Saunders Handbook of Veterinary Drugs, 4th edp.358 |
| • 5 mg/kg q12h PO. In refractory cases, increase dose to 10 mg/kg q12h PO. |
| 10 | — | Papich Saunders Handbook of Veterinary Drugs, 4th edp.358 | • Blastomycosis: 10 mg/kg per day. |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.