Fluconazole for Dogs

Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg

Fluconazole is dosed at 5–10 mg/kg IV q12-24h in dogs, per Mazepa AS, Trepanier LA, Foy DS. Retrospective comparison of the efficacy of fluconazole or itraconazole for the treatment of systemic blastomycosis in dogs. J Vet Intern Med. 2011;25(3):440-445. doi:10.1111/j.1939-1676.2011.0710.x; Wilson AG, KuKanich KS, Hanzlicek AS, Payton ME. Clinical signs, treatment, and prognostic factors for dogs with histoplasmosis. J Am Vet Med Assoc. 2018;252:201-209. doi:10.2460/javma.252.2.201 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.559 (2026-08-01).. Fluconazole is used in dogs for Severe CNS fungal infections, Coccidioidomycosis (Valley Fever), Cryptococcosis, Systemic fungal infections, CNS fungal infections. Routes documented in dogs: IV, PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 5 cited dose rules for Fluconazole in dogs, drawn from published veterinary references. Verify against current literature before clinical use.

US trade names: Diflucan

Dose ranges

Route	Dose	Frequency	Duration	Indication	Evidence	Source
IV	5–10 mg/kg	q12-24h	Until oral feasible

Side effects & warnings

Hepatotoxic: monitor liver enzymes during prolonged therapy. Drug interactions via CYP450 inhibition. Good CNS and ocular penetration.

Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.

Frequently asked questions

What is the dose of Fluconazole for Dogs?

Fluconazole dose ranges in dogs, with cited source references: IV 5–10 mg/kg q12-24h; PO 5–10 mg/kg q12h; PO 5–10 mg/kg q12h; PO 5–10 mg/kg q12-24h. Reference ranges from cited sources — verify against current literature before clinical use.

How is Fluconazole administered in Dogs?

Documented routes for Fluconazole in dogs: IV, PO.

How long is Fluconazole given in Dogs?

Cited course lengths for Fluconazole in dogs include: Until oral feasible; 12+ months; lifelong in some cases; Months; until antigen titers negative; Weeks to months depending on infection. Duration depends on the indication — match it to the specific dose rule in the table above.

What conditions does Fluconazole treat in Dogs?

Fluconazole is indicated in dogs for: Severe CNS fungal infections, Coccidioidomycosis (Valley Fever), Cryptococcosis, Systemic fungal infections, CNS fungal infections, Blastomycosis (CNS involvement adjunct).

What are the side effects of Fluconazole in Dogs?

These are general warnings for Fluconazole across species; consult the dog dosing table above for species-specific guidance. Hepatotoxic: monitor liver enzymes during prolonged therapy. Drug interactions via CYP450 inhibition. Good CNS and ocular penetration.

Why a species-specific page? Fluconazole pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.