Cat · Felis catus · typical adult weight 2.50–7.00 kg
Fluconazole is dosed at 5–10 mg/kg IV q12-24h in cats, per Plumb's Veterinary Drug Handbook, 9th Ed. Fluconazole is used in cats for Severe systemic mycoses, CNS cryptococcosis, Cryptococcosis, dermatophytosis, Nasal cryptococcosis. Routes documented in cats: IV, PO. A typical adult cat weighs 2.50–7.00 kg. ExoticRx lists 4 cited dose rules for Fluconazole in cats, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Diflucan
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 5–10 mg/kg | q12-24h | Until oral feasible | Severe systemic mycoses | Moderate | Plumb's Veterinary Drug Handbook, 9th Ed |
| PO | 10–15 mg/kg | q12h | 6+ months; until antigen negative | CNS cryptococcosis | Strong | Plumb's Veterinary Drug Handbook, 9th Ed |
| PO | 5–10 mg/kg | q12-24h | Weeks to months | Cryptococcosis, dermatophytosis | Strong | Vaden SL, Heit MC, Hawkins EC, Manaugh C, Riviere JE. Fluconazole in cats: Pharmacokinetics following intravenous and oral administration and penetration into cerebrospinal fluid, aqueous humour and pulmonary epithelial lining fluid. J Vet Pharmacol Ther. 1997;20(3):181-186. doi:10.1111/j.1365-2885.1997.tb00093.x — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.559 (2026-08-01). |
| PO | 5–10 mg/kg | q12h | Until antigen titers negative | Nasal cryptococcosis | Strong | Vaden SL, Heit MC, Hawkins EC, Manaugh C, Riviere JE. Fluconazole in cats: Pharmacokinetics following intravenous and oral administration and penetration into cerebrospinal fluid, aqueous humour and pulmonary epithelial lining fluid. J Vet Pharmacol Ther. 1997;20(3):181-186. doi:10.1111/j.1365-2885.1997.tb00093.x — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.559 (2026-08-01). |
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These ranges are per kg. Enter your cat's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Inhibits fungal cytochrome P450 enzyme 14-alpha-demethylase, blocking ergosterol synthesis and disrupting fungal cell membrane.
Hepatotoxic: monitor liver enzymes during prolonged therapy. Drug interactions via CYP450 inhibition. Good CNS and ocular penetration.
Species-specific contraindications and adverse-reaction reports for cats may differ from canine / feline reference data — consult the primary citations listed with each rule.
Fluconazole dose ranges in cats, with cited source references: IV 5–10 mg/kg q12-24h; PO 10–15 mg/kg q12h; PO 5–10 mg/kg q12-24h; PO 5–10 mg/kg q12h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Fluconazole in cats: IV, PO.
Cited course lengths for Fluconazole in cats include: Until oral feasible; 6+ months; until antigen negative; Weeks to months; Until antigen titers negative. Duration depends on the indication — match it to the specific dose rule in the table above.
Fluconazole is indicated in cats for: Severe systemic mycoses, CNS cryptococcosis, Cryptococcosis, dermatophytosis, Nasal cryptococcosis.
These are general warnings for Fluconazole across species; consult the cat dosing table above for species-specific guidance. Hepatotoxic: monitor liver enzymes during prolonged therapy. Drug interactions via CYP450 inhibition. Good CNS and ocular penetration.
Why a species-specific page? Fluconazole pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in cats — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.