Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Flucytosine is used in dog for Cryptococcosis (with amphotericin B). Routes documented in dog: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Flucytosine in dog, drawn from published veterinary references. Verify against current literature before clinical use.
Trade names: Ancobon
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 25–50 mg/kg | q6-8h | Weeks to months | Cryptococcosis (with amphotericin B) | Moderate | Plumb's Veterinary Drug Handbook, 9th Ed |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Converted to 5-fluorouracil inside fungal cells, inhibiting DNA and RNA synthesis. Synergistic with amphotericin B.
Rapid resistance if used alone — always combine with amphotericin B or azole. Bone marrow suppression, GI toxicity. Monitor CBC. Teratogenic.
Species-specific contraindications and adverse-reaction reports for dog may differ from canine / feline reference data — consult the primary citations listed with each rule.
Why a species-specific page? Flucytosine pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dog — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.