Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Flucytosine is dosed at 25–50 mg/kg PO q6-8h in dogs, per Muller & Kirk's Small Animal Dermatology, 7th ed. (2013), printed p.229 (corpus derm p.241), FLUCYTOSINE — "DOSAGE 25 to 50 mg/kg PO every 6 hours or 60 mg/kg every 8 hours given in combination with amphotericin B." Same entry, SIDE EFFECTS: "Fixed drug eruptions on the scrotum of dogs and toxic epidermal necrolysis have occurred." — SOURCE EDITION: Muller & Kirk's Small Animal Dermatology — ISBN 9781416000280, https://openlibrary.org/isbn/9781416000280. Flucytosine is used in dogs for Cryptococcosis (with amphotericin B). Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Flucytosine in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Ancobon
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 25–50 mg/kg | q6-8h | Weeks to months | Cryptococcosis (with amphotericin B) | Weak | Muller & Kirk's Small Animal Dermatology, 7th ed. (2013), printed p.229 (corpus derm p.241), FLUCYTOSINE — "DOSAGE 25 to 50 mg/kg PO every 6 hours or 60 mg/kg every 8 hours given in combination with amphotericin B." Same entry, SIDE EFFECTS: "Fixed drug eruptions on the scrotum of dogs and toxic epidermal necrolysis have occurred." — SOURCE EDITION: Muller & Kirk's Small Animal Dermatology — ISBN 9781416000280, https://openlibrary.org/isbn/9781416000280 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 25–35 | IV | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.184 | 25-35 mg/kg i.v. q8h or 50-65 mg/kg p.o. q8h |
| 50–65 | PO | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.184 | 25-35 mg/kg i.v. q8h or 50-65 mg/kg p.o. q8h |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.
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Converted to 5-fluorouracil inside fungal cells, inhibiting DNA and RNA synthesis. Synergistic with amphotericin B.
Rapid resistance if used alone — always combine with amphotericin B or azole. Bone marrow suppression, GI toxicity. Monitor CBC. Teratogenic.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Flucytosine dose range in dogs, with cited source references: PO 25–50 mg/kg q6-8h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Flucytosine in dogs: PO.
Cited course lengths for Flucytosine in dogs include: Weeks to months. Duration depends on the indication — match it to the specific dose rule in the table above.
Flucytosine is indicated in dogs for: Cryptococcosis (with amphotericin B).
These are general warnings for Flucytosine across species; consult the dog dosing table above for species-specific guidance. Rapid resistance if used alone — always combine with amphotericin B or azole. Bone marrow suppression, GI toxicity. Monitor CBC. Teratogenic.
Why a species-specific page? Flucytosine pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.