ExoticRx · exoticrx.com/drugs/flucytosine
US brand names:Ancobon
Flucytosine is dosed at 50 mg/kg PO q12h x 14-28 days in african grey parrots, per 665. Orosz SE, Frazier DL. Antifungal agents: a review of their pharmacology and therapeutic indications. J Avian Med Surg. 1995;9:8-18. — Source: Carpenter's Exotic Animal Formulary, 6th Ed, p.425 — Carpenter's Exotic Animal Formulary 6th ed, Table 5.2 (Antifungal Agents Used in Birds). Verify against current literature before clinical use.
Converted to 5-fluorouracil inside fungal cells, inhibiting DNA and RNA synthesis. Synergistic with amphotericin B.
Rapid resistance if used alone — always combine with amphotericin B or azole. Bone marrow suppression, GI toxicity. Monitor CBC. Teratogenic.
Species references:All African Grey Parrot drugsAll Cat (Domestic) drugsAll Chicken (Poultry) drugsAll Dog (Domestic) drugsAll Green-cheeked Conure drugsAll Lovebird drugsAll Turkey drugsAll Zebra Finch drugs
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| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Cat (Domestic) | PO | 25–50 mg/kg | q6-8h | Moderate | Pressler BM. Chapter 63: Candidiasis and Rhodotorulosis. In: Greene CE, ed. Infectious Diseases of the Dog and Cat. 4th ed. Elsevier; 2011:666-671. — Plumb's 10th ed printed p.534, Flucytosine monograph.Compilation only — we have not located an independent source that prints this figure. |
| Dog (Domestic) | PO | 25–50 mg/kg | q6-8h | Weak | Muller & Kirk's Small Animal Dermatology, 7th ed. (2013), printed p.229, FLUCYTOSINE — "DOSAGE 25 to 50 mg/kg PO every 6 hours or 60 mg/kg every 8 hours given in combination with amphotericin B." Same entry, SIDE EFFECTS: "Fixed drug eruptions on the scrotum of dogs and toxic epidermal necrolysis have occurred."Compilation only — we have not located an independent source that prints this figure. |
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