ExoticRx · exoticrx.com/drugs/flucytosine
US brand names:Ancobon
Flucytosine is dosed at 25–50 mg/kg PO q6-8h in dogs, per Plumb's Veterinary Drug Handbook, 9th Ed. Verify against current literature before clinical use.
Converted to 5-fluorouracil inside fungal cells, inhibiting DNA and RNA synthesis. Synergistic with amphotericin B.
Rapid resistance if used alone — always combine with amphotericin B or azole. Bone marrow suppression, GI toxicity. Monitor CBC. Teratogenic.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 25–50 mg/kg | q6-8h | Moderate | Plumb's Veterinary Drug Handbook, 9th Ed |
| Cat (Domestic) | PO | 25–50 mg/kg | q6-8h | Moderate | Pressler BM. Chapter 63: Candidiasis and Rhodotorulosis. In: Greene CE, ed. Infectious Diseases of the Dog and Cat. 4th ed. Elsevier; 2011:666-671. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.562 (2026-08-01). |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.