ExoticRx · exoticrx.com/drugs/amphotericin-b-lipid-complex
US brand names:Abelcet
Amphotericin B Lipid Complex is dosed at 1–1.5 mg/kg IV q48h or 3x/week in cats, per Foy DS, Trepanier LA. Antifungal Treatment of Small Animal Veterinary Patients. Veterinary Clinics of North America-Small Animal Practice. 2010;40(6):1171-1188. doi:10.1016/j.cvsm.2010.07.006 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.103 (2026-08-01). — figure located 2026-08-05 at Plumb's 10th ed printed p.77, Amphotericin B monograph; the page cited previously does not carry it. — Plumb's 10th ed (held) printed p.74, Amphotericin B monograph spanning p.74-77; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Verify against current literature before clinical use.
Binds ergosterol creating membrane pores. Lipid complex formulation reduces nephrotoxicity by preferentially distributing to RES tissues.
Less nephrotoxic than conventional amphotericin B but still significant. Infusion reactions. Monitor renal function and electrolytes.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Cat (Domestic) | IV | 1–1.5 mg/kg | q48h or 3x/week | Moderate | Foy DS, Trepanier LA. Antifungal Treatment of Small Animal Veterinary Patients. Veterinary Clinics of North America-Small Animal Practice. 2010;40(6):1171-1188. doi:10.1016/j.cvsm.2010.07.006 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.103 (2026-08-01). — figure located 2026-08-05 at Plumb's 10th ed printed p.77, Amphotericin B monograph; the page cited previously does not carry it. — Plumb's 10th ed (held) printed p.74, Amphotericin B monograph spanning p.74-77; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
| Dog (Domestic) | IV | 1–3 mg/kg | q48h or 3x/week |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.
| Krawiec DR, McKiernan BC, Twardock AR, et al. Use of an amphotericin B lipid complex for treatment of blastomycosis in dogs. J Am Vet Med Assoc. 1996;209(12):2073-2075. doi:10.2460/javma.1996.209.12.2073 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.103 (2026-08-01). — Plumb's 10th ed (held) printed p.74, Amphotericin B monograph spanning p.74-77; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |