Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Itraconazole is dosed at 5–10 mg/kg PO q12-24h in dogs, per Plumb's Veterinary Drug Handbook, 10th ed (2023, held copy; the original seed cited the 9th, which was never consulted) — Plumb's 10th ed (held) printed p.707, Itraconazole monograph spanning p.704-708; page located 2026-08-05 from the book's own running heads, and carries this exact dose under the matching species heading. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Itraconazole is used in dogs for Blastomycosis, histoplasmosis, dermatophytosis, Histoplasmosis, Blastomycosis / susceptible systemic mycoses NOT involving the CNS, Aspergillosis (nasal). Routes documented in dogs: PO, PO with food. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 4 cited dose rules for Itraconazole in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Sporanox, Itrafungol
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 5–10 mg/kg | q12-24h | Months | Blastomycosis, histoplasmosis, dermatophytosis |
| Plumb's Veterinary Drug Handbook, 10th ed (2023, held copy; the original seed cited the 9th, which was never consulted) — Plumb's 10th ed (held) printed p.707, Itraconazole monograph spanning p.704-708; page located 2026-08-05 from the book's own running heads, and carries this exact dose under the matching species heading. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
| PO | 5–10 mg/kg | q12h | 4-6 months minimum | Histoplasmosis | Strong | Plumb's Veterinary Drug Handbook, 10th ed (2023, held copy; the original seed cited the 9th, which was never consulted) — Plumb's 10th ed (held) printed p.707, Itraconazole monograph spanning p.704-708; page located 2026-08-05 from the book's own running heads, and carries this exact dose under the matching species heading. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
| PO | 5–10 mg/kg/day | q24h (or the same TOTAL DAILY dose divided q12h) | 6+ months; add fluconazole for CNS | Blastomycosis / susceptible systemic mycoses NOT involving the CNS | Weak | Plumb's Veterinary Drug Handbook, 10th ed., Itraconazole, printed p.707 (corpus PDF p.734), DOGS / Susceptible systemic mycoses. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
| PO with food | 5–10 mg/kg/DAY | q24h (or the same daily total divided q12h) | 3-6 months | Aspergillosis (nasal) | Weak | Plumb's Veterinary Drug Handbook, 10th ed (2023, held copy; the original seed cited the 9th, which was never consulted), printed p.707 (corpus p.734), DOGS - Susceptible systemic mycoses (extra-label). No superscript is printed on this dose sentence. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
The sources disagree for this combination. The ranges below do not overlap on a comparable route. This is not an error in one of them — published veterinary references differ, and reconciling them for a particular patient is a clinical judgement.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 5 | PO | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.231 | 5 mg/kg p.o. q24h. 4-20 weeks of treatment may be needed, dependent upon culture results. Pulse d |
| 2.5 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.447 | • 2.5 mg/kg q12h or 5 mg/kg q24h PO. For refractory cases, use 10 mg/kg q12h |
| 5 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.447 | • 2.5 mg/kg q12h or 5 mg/kg q24h PO. For refractory cases, use 10 mg/kg q12h |
| 10 |
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Inhibits fungal 14-alpha-demethylase, blocking ergosterol synthesis. Lipophilic with high tissue concentrations.
Hepatotoxic: monitor liver enzymes. Requires acid pH for capsule absorption (give with food). Negative inotropic effect — avoid in animals with heart failure. CYP3A4 inhibitor.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Itraconazole dose ranges in dogs, with cited source references: PO 5–10 mg/kg q12-24h; PO 5–10 mg/kg q12h; PO 5–10 mg/kg/day q24h (or the same TOTAL DAILY dose divided q12h); PO with food 5–10 mg/kg/DAY q24h (or the same daily total divided q12h). Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Itraconazole in dogs: PO, PO with food.
Cited course lengths for Itraconazole in dogs include: Months; 4-6 months minimum; 6+ months; add fluconazole for CNS; 3-6 months. Duration depends on the indication — match it to the specific dose rule in the table above.
Itraconazole is indicated in dogs for: Blastomycosis, histoplasmosis, dermatophytosis, Histoplasmosis, Blastomycosis / susceptible systemic mycoses NOT involving the CNS, Aspergillosis (nasal).
These are general warnings for Itraconazole across species; consult the dog dosing table above for species-specific guidance. Hepatotoxic: monitor liver enzymes. Requires acid pH for capsule absorption (give with food). Negative inotropic effect — avoid in animals with heart failure. CYP3A4 inhibitor.
Why a species-specific page? Itraconazole pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.
| PO |
| Papich Saunders Handbook of Veterinary Drugs, 4th edp.447 |
| • 2.5 mg/kg q12h or 5 mg/kg q24h PO. For refractory cases, use 10 mg/kg q12h |
| 3 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.447 | • Dermatophytes: 3 mg/kg/day, PO, for 15 days. |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.