Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Itraconazole is dosed at 5–10 mg/kg PO q12-24h in dogs, per Plumb's Veterinary Drug Handbook, 9th Ed. Itraconazole is used in dogs for Blastomycosis, histoplasmosis, dermatophytosis, Blastomycosis (CNS involvement), Histoplasmosis, Aspergillosis (nasal). Routes documented in dogs: PO, PO with food. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 4 cited dose rules for Itraconazole in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Sporanox, Itrafungol
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 5–10 mg/kg | q12-24h | Months | Blastomycosis, histoplasmosis, dermatophytosis | Strong | Plumb's Veterinary Drug Handbook, 9th Ed |
| PO | 5–10 mg/kg/day | q24h (or the same TOTAL DAILY dose divided q12h) | 6+ months; add fluconazole for CNS | Blastomycosis (CNS involvement) | Moderate | Plumb's Veterinary Drug Handbook, 10th ed., Itraconazole, printed p.707 (corpus PDF p.734), DOGS / Susceptible systemic mycoses. |
| PO | 5–10 mg/kg | q12h | 4-6 months minimum | Histoplasmosis | Strong | Plumb's Veterinary Drug Handbook, 9th Ed |
| PO with food | 5–10 mg/kg/DAY | q24h (or the same daily total divided q12h) | 3-6 months | Aspergillosis (nasal) | Moderate | Plumb's Veterinary Drug Handbook, 9th Ed, printed p.707 (corpus p.734), DOGS - Susceptible systemic mycoses (extra-label). No superscript is printed on this dose sentence. |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Inhibits fungal 14-alpha-demethylase, blocking ergosterol synthesis. Lipophilic with high tissue concentrations.
Hepatotoxic: monitor liver enzymes. Requires acid pH for capsule absorption (give with food). Negative inotropic effect — avoid in animals with heart failure. CYP3A4 inhibitor.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Itraconazole dose ranges in dogs, with cited source references: PO 5–10 mg/kg q12-24h; PO 5–10 mg/kg/day q24h (or the same TOTAL DAILY dose divided q12h); PO 5–10 mg/kg q12h; PO with food 5–10 mg/kg/DAY q24h (or the same daily total divided q12h). Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Itraconazole in dogs: PO, PO with food.
Cited course lengths for Itraconazole in dogs include: Months; 6+ months; add fluconazole for CNS; 4-6 months minimum; 3-6 months. Duration depends on the indication — match it to the specific dose rule in the table above.
Itraconazole is indicated in dogs for: Blastomycosis, histoplasmosis, dermatophytosis, Blastomycosis (CNS involvement), Histoplasmosis, Aspergillosis (nasal).
These are general warnings for Itraconazole across species; consult the dog dosing table above for species-specific guidance. Hepatotoxic: monitor liver enzymes. Requires acid pH for capsule absorption (give with food). Negative inotropic effect — avoid in animals with heart failure. CYP3A4 inhibitor.
Why a species-specific page? Itraconazole pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.