Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Itraconazole is used in dog for Blastomycosis, histoplasmosis, dermatophytosis, Aspergillosis (nasal), Blastomycosis (CNS involvement), Histoplasmosis. Routes documented in dog: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 4 cited dose rules for Itraconazole in dog, drawn from published veterinary references. Verify against current literature before clinical use.
Trade names: Sporanox, Itrafungol
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 5–10 mg/kg | q12-24h | Months | Blastomycosis, histoplasmosis, dermatophytosis | Strong | Plumb's Veterinary Drug Handbook, 9th Ed |
| PO | 5–10 mg/kg | q12h | 3-6 months | Aspergillosis (nasal) | Moderate | Plumb's Veterinary Drug Handbook, 9th Ed |
| PO | 5–10 mg/kg | q12h | 6+ months; add fluconazole for CNS | Blastomycosis (CNS involvement) | Moderate | Plumb's Veterinary Drug Handbook, 9th Ed |
| PO | 5–10 mg/kg | q12h | 4-6 months minimum | Histoplasmosis | Strong | Plumb's Veterinary Drug Handbook, 9th Ed |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Inhibits fungal 14-alpha-demethylase, blocking ergosterol synthesis. Lipophilic with high tissue concentrations.
Hepatotoxic: monitor liver enzymes. Requires acid pH for capsule absorption (give with food). Negative inotropic effect — avoid in animals with heart failure. CYP3A4 inhibitor.
Species-specific contraindications and adverse-reaction reports for dog may differ from canine / feline reference data — consult the primary citations listed with each rule.
Why a species-specific page? Itraconazole pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dog — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.