Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Leptospira Vaccine is used in dog for Leptospirosis prevention, Leptospirosis (booster protocol). Routes documented in dog: SC. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 2 cited dose rules for Leptospira Vaccine in dog, drawn from published veterinary references. Verify against current literature before clinical use.
Trade names: Nobivac Lepto4, Vanguard L4
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| SC | 1 dose | 2 doses 2-4 weeks apart; then annually | Two-dose primary series 2-4 weeks apart starting at 12 weeks; annual boosters required | Leptospirosis prevention | Strong | AAHA Canine Vaccination Guidelines 2022 |
| SC | 1 dose | Annually | ANNUAL boosters required — immunity wanes faster than core vaccines | Leptospirosis (booster protocol) | Strong | AAHA Canine Vaccination Guidelines 2022 |
Need the exact dose for your patient?
These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Inactivated Leptospira serovars (canicola, grippotyphosa, icterohaemorrhagiae, pomona) stimulating active immunity and reducing shedding.
Higher anaphylaxis risk than other canine vaccines — especially in small breeds. Administer separately from other vaccines if possible. Annual boosters required.
Species-specific contraindications and adverse-reaction reports for dog may differ from canine / feline reference data — consult the primary citations listed with each rule.
Why a species-specific page? Leptospira Vaccine pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dog — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.