What is Lotilaner used for?

Lotilaner is indicated for: Demodex, Flea and tick prevention, Sarcoptes.

Which species have cited Lotilaner dosing data?

Lotilaner dosing in the ExoticRx formulary covers 1 species: Dog (Domestic).

Is Lotilaner a controlled substance?

Lotilaner is not federally scheduled in the US. Controlled-drug status differs by country — verify your local rules.

What are the side effects of Lotilaner?

Reported side effects, adverse reactions, and contraindications for Lotilaner: Seizure potential in dogs with history of neurologic disorders. Administer with food. Not for use in puppies <8 weeks or <1.4kg.

How does Lotilaner work?

Isoxazoline ectoparasiticide blocking GABA and glutamate-gated chloride channels. Monthly flea and tick protection.

Lotilaner

US brand names:Credelio

Calculate dosage

Sourced from published veterinary references. Awaiting credentialed clinical reviewer — our editorial process.

Lotilaner is dosed at 20–43 mg/kg PO q30 days in dogs, per CREDELIO - Lotilaner Tablet, Chewable [US Canine Product Label]. Elanco US Inc; 2017. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ad403eb7-0c03-4bda-9698-3757860043cf — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.811 (2026-08-01).. Verify against current literature before clinical use.

Drug Class

Antiparasitic

Routes

Indications

DemodexFlea and tick preventionSarcoptes

Side effects & warnings

Seizure potential in dogs with history of neurologic disorders. Administer with food. Not for use in puppies <8 weeks or <1.4kg.

Evidence levels across 2 dose rules

Moderate×1Strong×1

Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.

Backed by a published source

· CREDELIO - Lotilaner Tablet, Chewable [US Canine Product Label]. Elanco US Inc; 2017. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ad403eb7-0c03-4bda-9698-3757860043cf — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.811 (2026-08-01).

Sample dosing (2 of 2 cited rules)

A dog/cat sample is shown here. Cited dosing for all 1 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.

Species	Route	Dose	Frequency	Evidence	Source
Dog (Domestic)	PO	20–43 mg/kg	q30 days	Strong	CREDELIO - Lotilaner Tablet, Chewable [US Canine Product Label]. Elanco US Inc; 2017. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ad403eb7-0c03-4bda-9698-3757860043cf — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.811 (2026-08-01).
Dog (Domestic)	PO	20–43 mg/kg	q30 days	Moderate	CREDELIO - Lotilaner Tablet, Chewable [US Canine Product Label]. Elanco US Inc; 2017. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ad403eb7-0c03-4bda-9698-3757860043cf — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.811 (2026-08-01).

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Lotilaner

Drug Class

Routes

Indications

Mechanism of Action

Side effects & warnings

Species with Lotilaner dosing data (2 dose rules)

Evidence levels across 2 dose rules

Backed by a published source

Sample dosing (2 of 2 cited rules)

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Lotilaner

Drug Class

Routes

Indications

Mechanism of Action

Side effects & warnings

Species with Lotilaner dosing data (2 dose rules)

Evidence levels across 2 dose rules

Backed by a published source

Sample dosing (2 of 2 cited rules)

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