Question 1

What is Lotilaner used for?

Accepted Answer

Lotilaner is indicated for: Demodex, Flea and tick prevention, Sarcoptes.

Question 2

What routes can Lotilaner be administered by?

Accepted Answer

Available routes: PO.

Question 3

Which species have cited Lotilaner dosing data?

Accepted Answer

Lotilaner dosing in the ExoticRx formulary covers 1 species: Dog (Domestic).

Question 4

Is Lotilaner a controlled substance?

Accepted Answer

Lotilaner is not federally scheduled as a controlled substance, but is veterinary prescription only in most jurisdictions.

Question 5

What are the warnings or contraindications for Lotilaner?

Accepted Answer

Seizure potential in dogs with history of neurologic disorders. Administer with food. Not for use in puppies <8 weeks or <1.4kg.

Question 6

What are the side effects of Lotilaner?

Accepted Answer

Reported side effects, adverse reactions, and contraindications for Lotilaner: Seizure potential in dogs with history of neurologic disorders. Administer with food. Not for use in puppies <8 weeks or <1.4kg.

Question 7

How does Lotilaner work?

Accepted Answer

Isoxazoline ectoparasiticide blocking GABA and glutamate-gated chloride channels. Monthly flea and tick protection.

Species	Route	Dose	Frequency	Evidence	Source
Dog (Domestic)	PO	20–43 mg/kg	q30 days	Strong	Plumb's Veterinary Drug Handbook, 9th Ed
Dog (Domestic)	PO	20–43 mg/kg	q30 days	Moderate	Plumb's Veterinary Drug Handbook, 9th Ed

Lotilaner

Drug Class

Routes

Indications

Mechanism of Action

Side effects & warnings

Species with Lotilaner dosing data (2 dose rules)

Evidence levels across 2 dose rules

Backed by a published source

Sample dosing (2 of 2 cited rules)

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