Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Lotilaner is dosed at 20–43 mg/kg PO q30 days in dogs, per CREDELIO - Lotilaner Tablet, Chewable [US Canine Product Label]. Elanco US Inc; 2017. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ad403eb7-0c03-4bda-9698-3757860043cf — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.811 (2026-08-01). — Plumb's 10th ed (held) printed p.783, Lotilaner monograph spanning p.783-784; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Lotilaner is used in dogs for Flea and tick prevention, Demodex, Sarcoptes. Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 2 cited dose rules for Lotilaner in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Credelio
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 20–43 mg/kg | q30 days | Monthly | Flea and tick prevention | Strong | CREDELIO - Lotilaner Tablet, Chewable [US Canine Product Label]. Elanco US Inc; 2017. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ad403eb7-0c03-4bda-9698-3757860043cf — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.811 (2026-08-01). — Plumb's 10th ed (held) printed p.783, Lotilaner monograph spanning p.783-784; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
| PO | 20–43 mg/kg | q30 days | Until resolved + 1 month | Demodex, Sarcoptes | Moderate | CREDELIO - Lotilaner Tablet, Chewable [US Canine Product Label]. Elanco US Inc; 2017. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ad403eb7-0c03-4bda-9698-3757860043cf — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.811 (2026-08-01). — Plumb's 10th ed (held) printed p.783, Lotilaner monograph spanning p.783-784; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 20–43 | — | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.254 | 20-43 mg/kg monthly. |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Isoxazoline ectoparasiticide blocking GABA and glutamate-gated chloride channels. Monthly flea and tick protection.
Seizure potential in dogs with history of neurologic disorders. Administer with food. Not for use in puppies <8 weeks or <1.4kg.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Lotilaner dose ranges in dogs, with cited source references: PO 20–43 mg/kg q30 days; PO 20–43 mg/kg q30 days. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Lotilaner in dogs: PO.
Cited course lengths for Lotilaner in dogs include: Monthly; Until resolved + 1 month. Duration depends on the indication — match it to the specific dose rule in the table above.
Lotilaner is indicated in dogs for: Flea and tick prevention, Demodex, Sarcoptes.
These are general warnings for Lotilaner across species; consult the dog dosing table above for species-specific guidance. Seizure potential in dogs with history of neurologic disorders. Administer with food. Not for use in puppies <8 weeks or <1.4kg.
Why a species-specific page? Lotilaner pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.