Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Lotilaner is dosed at 20–43 mg/kg PO q30 days in dogs, per CREDELIO - Lotilaner Tablet, Chewable [US Canine Product Label]. Elanco US Inc; 2017. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ad403eb7-0c03-4bda-9698-3757860043cf — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.811 (2026-08-01).. Lotilaner is used in dogs for Flea and tick prevention, Demodex, Sarcoptes. Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 2 cited dose rules for Lotilaner in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Credelio
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 20–43 mg/kg | q30 days | Monthly | Flea and tick prevention | Strong | CREDELIO - Lotilaner Tablet, Chewable [US Canine Product Label]. Elanco US Inc; 2017. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.811 (2026-08-01). |
| PO | 20–43 mg/kg | q30 days | Until resolved + 1 month | Demodex, Sarcoptes | Moderate | CREDELIO - Lotilaner Tablet, Chewable [US Canine Product Label]. Elanco US Inc; 2017. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ad403eb7-0c03-4bda-9698-3757860043cf — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.811 (2026-08-01). |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Isoxazoline ectoparasiticide blocking GABA and glutamate-gated chloride channels. Monthly flea and tick protection.
Seizure potential in dogs with history of neurologic disorders. Administer with food. Not for use in puppies <8 weeks or <1.4kg.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Lotilaner dose ranges in dogs, with cited source references: PO 20–43 mg/kg q30 days; PO 20–43 mg/kg q30 days. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Lotilaner in dogs: PO.
Cited course lengths for Lotilaner in dogs include: Monthly; Until resolved + 1 month. Duration depends on the indication — match it to the specific dose rule in the table above.
Lotilaner is indicated in dogs for: Flea and tick prevention, Demodex, Sarcoptes.
These are general warnings for Lotilaner across species; consult the dog dosing table above for species-specific guidance. Seizure potential in dogs with history of neurologic disorders. Administer with food. Not for use in puppies <8 weeks or <1.4kg.
Why a species-specific page? Lotilaner pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.