ExoticRx · exoticrx.com/drugs/lotilaner-moxidectin
US brand names:Credelio Plus
Lotilaner-Moxidectin is dosed at Dose as printed in that source: "Credelio Quattro/Credelio Quattro-CA1 is given orally at the minimum dosage of 9 mg/lb (20 mg/kg) lotilaner, 0.009 mg/lb (0.02 mg/kg) moxidectin, 2.28 mg/lb (5 mg/kg) praziquantel, and 2.28 mg/lb (5 mg/kg) pyrantel (as pamoate salt)." Administered once monthly; dosing table covers five weight bands 3.3-6, 6.1-12, 12.1-25, 25.1-50 and 50.1-100 lb in dogs, per CREDELIO QUATTRO (lotilaner, moxidectin, praziquantel, and pyrantel chewable) Tablet — Elanco US Inc. PRESCRIPTION ANIMAL DRUG LABEL, NADA 141-581 https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ad403eb7-0c03-4bda-9698-3757860043cf. Verify against current literature before clinical use.
Lotilaner (isoxazoline) for ectoparasite control via GABA/glutamate channel blockade; moxidectin for heartworm prevention and intestinal nematode treatment.
Dogs only. Monthly chewable. Seizure caution (isoxazoline class). Do not use in dogs <8 weeks or <1.4 kg.
Species references:All Dog (Domestic) drugs
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| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | Dose as printed in that source: "Credelio Quattro/Credelio Quattro-CA1 is given orally at the minimum dosage of 9 mg/lb (20 mg/kg) lotilaner, 0.009 mg/lb (0.02 mg/kg) moxidectin, 2.28 mg/lb (5 mg/kg) praziquantel, and 2.28 mg/lb (5 mg/kg) pyrantel (as pamoate salt)." Administered once monthly; dosing table covers five weight bands 3.3-6, 6.1-12, 12.1-25, 25.1-50 and 50.1-100 lb | q30 days | Strong | CREDELIO QUATTRO (lotilaner, moxidectin, praziquantel, and pyrantel chewable) Tablet — Elanco US Inc. PRESCRIPTION ANIMAL DRUG LABEL, NADA 141-581 https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ad403eb7-0c03-4bda-9698-3757860043cf |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.