Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Lotilaner-Moxidectin is dosed at Dose as printed in that source: "Credelio Quattro/Credelio Quattro-CA1 is given orally at the minimum dosage of 9 mg/lb (20 mg/kg) lotilaner, 0.009 mg/lb (0.02 mg/kg) moxidectin, 2.28 mg/lb (5 mg/kg) praziquantel, and 2.28 mg/lb (5 mg/kg) pyrantel (as pamoate salt)." Administered once monthly; dosing table covers five weight bands 3.3-6, 6.1-12, 12.1-25, 25.1-50 and 50.1-100 lb in dogs, per CREDELIO QUATTRO (lotilaner, moxidectin, praziquantel, and pyrantel chewable) Tablet — Elanco US Inc. PRESCRIPTION ANIMAL DRUG LABEL, NADA 141-581 https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ad403eb7-0c03-4bda-9698-3757860043cf. Lotilaner-Moxidectin is used in dogs for Fleas, ticks, heartworm. Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Lotilaner-Moxidectin in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Credelio Plus
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | Dose as printed in that source: "Credelio Quattro/Credelio Quattro-CA1 is given orally at the minimum dosage of 9 mg/lb (20 mg/kg) lotilaner, 0.009 mg/lb (0.02 mg/kg) moxidectin, 2.28 mg/lb (5 mg/kg) praziquantel, and 2.28 mg/lb (5 mg/kg) pyrantel (as pamoate salt)." Administered once monthly; dosing table covers five weight bands 3.3-6, 6.1-12, 12.1-25, 25.1-50 and 50.1-100 lb | q30 days | Monthly, year-round | Fleas, ticks, heartworm | Strong | CREDELIO QUATTRO (lotilaner, moxidectin, praziquantel, and pyrantel chewable) Tablet — Elanco US Inc. PRESCRIPTION ANIMAL DRUG LABEL, NADA 141-581 https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ad403eb7-0c03-4bda-9698-3757860043cf |
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Lotilaner (isoxazoline) for ectoparasite control via GABA/glutamate channel blockade; moxidectin for heartworm prevention and intestinal nematode treatment.
Dogs only. Monthly chewable. Seizure caution (isoxazoline class). Do not use in dogs <8 weeks or <1.4 kg.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Lotilaner-Moxidectin dose range in dogs, with cited source references: PO Dose as printed in that source: "Credelio Quattro/Credelio Quattro-CA1 is given orally at the minimum dosage of 9 mg/lb (20 mg/kg) lotilaner, 0.009 mg/lb (0.02 mg/kg) moxidectin, 2.28 mg/lb (5 mg/kg) praziquantel, and 2.28 mg/lb (5 mg/kg) pyrantel (as pamoate salt)." Administered once monthly; dosing table covers five weight bands 3.3-6, 6.1-12, 12.1-25, 25.1-50 and 50.1-100 lb q30 days. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Lotilaner-Moxidectin in dogs: PO.
Cited course lengths for Lotilaner-Moxidectin in dogs include: Monthly, year-round. Duration depends on the indication — match it to the specific dose rule in the table above.
Lotilaner-Moxidectin is indicated in dogs for: Fleas, ticks, heartworm.
These are general warnings for Lotilaner-Moxidectin across species; consult the dog dosing table above for species-specific guidance. Dogs only. Monthly chewable. Seizure caution (isoxazoline class). Do not use in dogs <8 weeks or <1.4 kg.
Why a species-specific page? Lotilaner-Moxidectin pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.