ExoticRx · exoticrx.com/drugs/lyme-disease-vaccine-borrelia
US brand names:Nobivac Lyme, Vanguard crLyme
Lyme Disease Vaccine (Borrelia) is dosed at 1 dose SC 2 doses 2-4wk apart at 12wk; annually in dogs, per 2022 AAHA Canine Vaccination Guidelines, American Animal Hospital Association (https://www.aaha.org/resources/2022-aaha-canine-vaccination-guidelines/), verified 2026-08-05; ACVIM Lyme Consensus. Verify against current literature before clinical use.
Recombinant OspA protein or killed whole-cell Borrelia burgdorferi inducing antibodies that kill spirochetes in the tick during feeding.
Recommended in endemic areas only. Two-dose primary series. Annual boosters required. Tick prevention still essential alongside vaccination.
Species references:All Dog (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 1 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | SC | 1 dose | 2 doses 2-4wk apart at 12wk; annually | Moderate | 2022 AAHA Canine Vaccination Guidelines, American Animal Hospital Association (https://www.aaha.org/resources/2022-aaha-canine-vaccination-guidelines/), verified 2026-08-05; ACVIM Lyme Consensus |
| Dog (Domestic) | SC | 1 dose | Annually before tick season | Moderate | 2022 AAHA Canine Vaccination Guidelines, American Animal Hospital Association (https://www.aaha.org/resources/2022-aaha-canine-vaccination-guidelines/), verified 2026-08-05 |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.