ExoticRx · exoticrx.com/drugs/macitentan
Opsumit
Dual endothelin receptor antagonist (ETA and ETB) with sustained receptor binding that reduces pulmonary vascular resistance and right heart afterload.
Hepatotoxicity — monthly LFT monitoring initially. Anemia possible. Teratogenic. Investigational for refractory canine pulmonary hypertension.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 0.5–1 mg/kg | q24h | Weak | Veterinary Cardiology Literature Review |
| Cat (Domestic) | PO | 0.5–1 mg/kg | q24h | Extrapolated | Veterinary Cardiology Literature Review |
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