ExoticRx · exoticrx.com/drugs/macitentan
US brand names:Opsumit
Macitentan is dosed at 0.5–1 mg/kg PO q24h in dogs, per Source not established. The citation previously shown here named no retrievable document; a literature search on 2026-07-31 found no source that states this dose for this species and route. Treat as unverified and confirm against a primary reference before clinical use.. Verify against current literature before clinical use.
Dual endothelin receptor antagonist (ETA and ETB) with sustained receptor binding that reduces pulmonary vascular resistance and right heart afterload.
Hepatotoxicity — monthly LFT monitoring initially. Anemia possible. Teratogenic. Investigational for refractory canine pulmonary hypertension.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
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A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 0.5–1 mg/kg | q24h | Weak | Source not established. The citation previously shown here named no retrievable document; a literature search on 2026-07-31 found no source that states this dose for this species and route. Treat as unverified and confirm against a primary reference before clinical use. |
| Cat (Domestic) | PO | 0.5–1 mg/kg | q24h | Extrapolated | Source not established. The citation previously shown here named no retrievable document; a literature search on 2026-07-31 found no source that states this dose for this species and route. Treat as unverified and confirm against a primary reference before clinical use. |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.