Cat · Felis catus · typical adult weight 2.50–7.00 kg
Macitentan is dosed at 0.5–1 mg/kg PO q24h in cats, per Source not established. The citation previously shown here named no retrievable document; a literature search on 2026-07-31 found no source that states this dose for this species and route. Treat as unverified and confirm against a primary reference before clinical use.. Macitentan is used in cats for Pulmonary hypertension (investigational). Routes documented in cats: PO. A typical adult cat weighs 2.50–7.00 kg. ExoticRx lists 1 cited dose rule for Macitentan in cats, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Opsumit
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 0.5–1 mg/kg | q24h | Investigational | Pulmonary hypertension (investigational) | Extrapolated | Source not established. The citation previously shown here named no retrievable document; a literature search on 2026-07-31 found no source that states this dose for this species and route. Treat as unverified and confirm against a primary reference before clinical use. |
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These ranges are per kg. Enter your cat's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Dual endothelin receptor antagonist (ETA and ETB) with sustained receptor binding that reduces pulmonary vascular resistance and right heart afterload.
Hepatotoxicity — monthly LFT monitoring initially. Anemia possible. Teratogenic. Investigational for refractory canine pulmonary hypertension.
Species-specific contraindications and adverse-reaction reports for cats may differ from canine / feline reference data — consult the primary citations listed with each rule.
Macitentan dose range in cats, with cited source references: PO 0.5–1 mg/kg q24h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Macitentan in cats: PO.
Cited course lengths for Macitentan in cats include: Investigational. Duration depends on the indication — match it to the specific dose rule in the table above.
Macitentan is indicated in cats for: Pulmonary hypertension (investigational).
These are general warnings for Macitentan across species; consult the cat dosing table above for species-specific guidance. Hepatotoxicity — monthly LFT monitoring initially. Anemia possible. Teratogenic. Investigational for refractory canine pulmonary hypertension.
Why a species-specific page? Macitentan pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in cats — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.