Cat · Felis catus · typical adult weight 2.50–7.00 kg
Macitentan is used in cat for Pulmonary hypertension (investigational). Routes documented in cat: PO. A typical adult cat weighs 2.50–7.00 kg. ExoticRx lists 1 cited dose rule for Macitentan in cat, drawn from published veterinary references. Verify against current literature before clinical use.
Trade names: Opsumit
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 0.5–1 mg/kg | q24h | Investigational | Pulmonary hypertension (investigational) | Extrapolated | Veterinary Cardiology Literature Review |
Need the exact dose for your patient?
These ranges are per kg. Enter your cat's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Dual endothelin receptor antagonist (ETA and ETB) with sustained receptor binding that reduces pulmonary vascular resistance and right heart afterload.
Hepatotoxicity — monthly LFT monitoring initially. Anemia possible. Teratogenic. Investigational for refractory canine pulmonary hypertension.
Species-specific contraindications and adverse-reaction reports for cat may differ from canine / feline reference data — consult the primary citations listed with each rule.
Why a species-specific page? Macitentan pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in cat — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.