ExoticRx · exoticrx.com/drugs/medetomidine-vatinoxan
US brand names:Zenalpha
Medetomidine provides alpha-2 mediated sedation and analgesia; vatinoxan blocks peripheral alpha-2 effects to maintain cardiac output and tissue perfusion.
Dogs only (FDA-approved). Reduced bradycardia compared to medetomidine alone. Reversible with atipamezole for central effects. Improved hemodynamic profile.
Species references:All Dog (Domestic) drugs
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| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | IM | See the cited source for the printed regimen | Single dose (weight-based) | Strong | ZENALPHA- Vatinoxan Hydrochloride and Medetomidine Hydrochloride Solution [US Product Label for Dogs]. Dechra Veterinary Products; 2021. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=623f44bf-07c7-4704-8114-5e42e1316fb1 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.840 (2026-08-01). — Plumb's 10th ed (held) printed p.811, Medetomidine/Vatinoxan monograph spanning p.811-813; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
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